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1 Copenhagen Muscle Research
Centre,
The purpose of this study was to examine whether microdialysis and the internal reference thallium-201 (201Tl) could accurately measure muscle interstitial K+ (K+i) before, during, and after exercise. The relative loss of 201Tl and simultaneous relative recovery of K+ were measured in vitro for 12 microdialysis probes that were bathed in Ringer acetate medium and perfused at various flows (3-10 µl/min). 201Tl loss was linearly related to K+ recovery, and their level of agreement was not different from zero. Microdialysis and 201Tl were then used to measure K+i in the gastrocnemius medialis muscle of four humans during rest and static plantar flexion exercise. At rest, K+i was 3.9-4.3 mmol/l when the perfusate flow was 2 or 5 µl/min. During exercise, K+i increased from 6.9 ± 0.4 to 7.5 ± 0.3 mmol/l at low to high intensity and declined to 5.2 ± 0.3 mmol/l after exercise. These results suggest that large changes in K+i in human skeletal muscle can be accurately measured by using microdialysis and 201Tl.
potassium; microdialysis; thallium
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