Journal of Applied Physiology
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J Appl Physiol 87: 444-451, 1999;
8750-7587/99 $5.00
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Vol. 87, Issue 1, 444-451, July 1999

SPECIAL COMMUNICATION
Monitoring respiratory function and sleep in the obese Vietnamese pot-bellied pig

Stephanie A. Tuck, Joseph C. Dort, Merle E. Olson, and John E. Remmers

Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

Development of drug treatments for obstructive sleep-disordered breathing has been impeded by the lack of animal models. The obese pig may be a suitable animal model, as it has been reported to experience sleep-disordered breathing resembling human obstructive sleep apnea. The purpose of this paper is to describe in detail techniques for chronic instrumentation of the obese Vietnamese pot-bellied pig and to study respiratory function during sleep. Under general anesthesia, four obese pigs were instrumented for long-term recording of intrapleural and tracheal pressures, genioglossal EMG, and bioelectric signals related to sleep. A custom-fitted face mask was used to record respiratory variables including airflow, snoring, and expired CO2. Most chronic instrumentation provided robust signals for up to 6 wk after installation. All pigs displayed sleep-disordered breathing characterized by increased resistance to airflow, snoring, inspiratory flow limitation, and possible sleep disruption. Apneas and hypopneas were not a feature of breathing during sleep in these animals. Nonetheless, this animal preparation may be useful for exploring possible drug treatments for obstructive sleep-disordered breathing.

upper airway resistance; sleep apnea syndromes; respiratory mechanics


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