Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 87: 222-226, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greiwe, J. S.
Right arrow Articles by Holloszy, J. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greiwe, J. S.
Right arrow Articles by Holloszy, J. O.
Vol. 87, Issue 1, 222-226, July 1999

Effects of endurance exercise training on muscle glycogen accumulation in humans

Jeffrey S. Greiwe, Robert C. Hickner, Polly A. Hansen, Susan B. Racette, May M. Chen, and John O. Holloszy

Washington University School of Medicine, St. Louis, Missouri 63110

The purpose of this investigation was to determine whether endurance exercise training increases the ability of human skeletal muscle to accumulate glycogen after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old) performed high-intensity stationary cycling 3 days/wk and continuous running 3 days/wk for 10 wk. Muscle glycogen concentration was measured after a glycogen-depleting exercise bout before and after endurance training. Muscle glycogen accumulation rate from 15 min to 6 h after exercise was twofold higher (P < 0.05) in the trained than in the untrained state: 10.5 ± 0.2 and 4.5 ± 1.3 mmol · kg wet wt-1 · h-1, respectively. Muscle glycogen concentration was higher (P < 0.05) in the trained than in the untrained state at 15 min, 6 h, and 48 h after exercise. Muscle GLUT-4 content after exercise was twofold higher (P < 0.05) in the trained than in the untrained state (10.7 ± 1.2 and 4.7 ± 0.7 optical density units, respectively) and was correlated with muscle glycogen concentration 6 h after exercise (r = 0.64, P < 0.05). Total glycogen synthase activity and the percentage of glycogen synthase I were not significantly different before and after training at 15 min, 6 h, and 48 h after exercise. We conclude that endurance exercise training enhances the capacity of human skeletal muscle to accumulate glycogen after glycogen-depleting exercise.

GLUT-4 glucose transporter; glycogen supercompensation; glycogen synthase activity


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Y. C. Long and J. R. Zierath
Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle
Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E545 - E552.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Physiol. Educ.Home page
G. A. Brown
Teaching skeletal muscle adaptations to aerobic exercise using an American Physiological Society classic paper by Dr. Philip Gollnick and colleagues
Advan Physiol Educ, September 1, 2006; 30(3): 113 - 118.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. E. Civitarese, M. K. C. Hesselink, A. P. Russell, E. Ravussin, and P. Schrauwen
Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes
Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1023 - E1029.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. T Fueger, J. Shearer, T. M Krueger, K. A Posey, D. P Bracy, S. Heikkinen, M. Laakso, J. N Rottman, and D. H Wasserman
Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse
J. Physiol., July 15, 2005; 566(2): 533 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. O. Holloszy
Exercise-induced increase in muscle insulin sensitivity
J Appl Physiol, July 1, 2005; 99(1): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
G. N. Kraniou, D. Cameron-Smith, and M. Hargreaves
Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle
Exp Physiol, September 1, 2004; 89(5): 559 - 563.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Otani, D.-H. Han, E. L. Ford, P. M. Garcia-Roves, H. Ye, Y. Horikawa, G. I. Bell, J. O. Holloszy, and K. S. Polonsky
Calpain System Regulates Muscle Mass and Glucose Transporter GLUT4 Turnover
J. Biol. Chem., May 14, 2004; 279(20): 20915 - 20920.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. Battram, J. Shearer, D. Robinson, and T. E. Graham
Caffeine ingestion does not impede the resynthesis of proglycogen and macroglycogen after prolonged exercise and carbohydrate supplementation in humans
J Appl Physiol, March 1, 2004; 96(3): 943 - 950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. M. Garcia-Roves, D.-H. Han, Z. Song, T. E. Jones, K. A. Hucker, and J. O. Holloszy
Prevention of glycogen supercompensation prolongs the increase in muscle GLUT4 after exercise
Am J Physiol Endocrinol Metab, October 1, 2003; 285(4): E729 - E736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. O. Holloszy
A forty-year memoir of research on the regulation of glucose transport into muscle
Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E453 - E467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. S. Fisher, L. A. Nolte, K. Kawanaka, D.-H. Han, T. E. Jones, and J. O. Holloszy
Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation
Am J Physiol Endocrinol Metab, June 1, 2002; 282(6): E1214 - E1221.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. L. Carter, C. Rennie, and M. A. Tarnopolsky
Substrate utilization during endurance exercise in men and women after endurance training
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E898 - E907.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Kawanaka, L. A. Nolte, D.-H. Han, P. A. Hansen, and J. O. Holloszy
Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1311 - E1318.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. J. O'Gorman, L. F. Del Aguila, D. L. Williamson, R. K. Krishnan, and J. P. Kirwan
Insulin and exercise differentially regulate PI3-kinase and glycogen synthase in human skeletal muscle
J Appl Physiol, October 1, 2000; 89(4): 1412 - 1419.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Kristiansen, J. Gade, J. F. P. Wojtaszewski, B. Kiens, and E. A. Richter
Glucose uptake is increased in trained vs. untrained muscle during heavy exercise
J Appl Physiol, September 1, 2000; 89(3): 1151 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Walker, G. J. F. Heigenhauser, E. Hultman, and L. L. Spriet
Dietary carbohydrate, muscle glycogen content, and endurance performance in well-trained women
J Appl Physiol, June 1, 2000; 88(6): 2151 - 2158.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Milan, J. Jeon, C. Looft, V. Amarger, A. Robic, M. Thelander, C. Rogel-Gaillard, S. Paul, N. Iannuccelli, L. Rask, et al.
A Mutation in PRKAG3 Associated with Excess Glycogen Content in Pig Skeletal Muscle
Science, May 19, 2000; 288(5469): 1248 - 1251.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
E. O. Ojuka, L. A. Nolte, and J. O. Holloszy
Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles exposed to AICAR in vitro
J Appl Physiol, March 1, 2000; 88(3): 1072 - 1075.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online