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Atelier de Physiologie Respiratoire, Faculté de Médecine Saint-Antoine, 75012 Paris, France
Because it
has been recently suggested that nitric oxide (NO) may mediate the
effects of hypoxia on body temperature and ventilation, the present
study was designed to assess more completely the effects of a neuronal
NO synthase inhibitor (7-nitroindazole, 25 mg/kg ip), at ambient
temperature of 26 and 15°C, on the ventilatory (
), metabolic
(O2 consumption), and thermal
changes (colonic and tail temperatures) induced by ambient hypoxia
(fractional inspired O2 of 11%)
or CO hypoxia (fractional inspired CO of 0.07%) in intact,
unanesthetized adult rats. At both ambient temperatures, 7-nitroindazole decreased oxygen consumption, colonic temperature, and
in normoxia. The drug reduced ambient or CO
hypoxia-induced hypometabolism and ventilatory response, but the
hypothermia persisted. It is concluded that NO arising from neural NO
synthase plays an important role in the control of metabolism and
in normoxia. As well, it mediates, in part, the
hypometabolic and the ventilatory response to hypoxia. The results are
consistent with the notion that central nervous system hypoxia resets
the thermoregulatory set point by decreasing brain NO.
thermoregulation; control of breathing; carbon monoxide; cold
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