Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 1984-1993, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nodelman, V.
Right arrow Articles by Ultman, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nodelman, V.
Right arrow Articles by Ultman, J. S.
Vol. 86, Issue 6, 1984-1993, June 1999

Longitudinal distribution of chlorine absorption in human airways: comparison of nasal and oral quiet breathing

Vladislav Nodelman and James S. Ultman

Biological Transport Dynamics Laboratory, Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania 16802

The fraction of an inspired chlorine (Cl2) bolus absorbed during a single breath (Lambda ) was measured as a function of bolus penetration (VP) into the respiratory system of five male and five female nonsmokers during both nasal and oral breathing at a quiet respiratory flow of 250 ml/s. The correspondence between VP and specific anatomic landmarks was found for each subject by a combination of acoustic reflection and nitrogen washout measurements. For both nasal and oral breathing, Lambda  reached ~0.95 at the distal end of the upper airways and reached 1.00 within the lower conducting airways. The values of a regional mass transfer parameter computed from the Lambda -VP data indicated that the resistance to Cl2 diffusion in the airway mucosa was negligible compared with the diffusion resistance in the respired gas. Changing the peak inhaled Cl2 concentration from 0.5 to 3.0 parts/million did not significantly affect the distribution of Cl2 absorption, suggesting that the underlying mass transport and chemical reaction processes were linear with respect to Cl2 concentration.

air pollution; inhalation toxicology; lung dosimetry; regional uptake; mass transfer coefficient; conducting airways


This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
D Shusterman
Trigeminally-mediated health effects of air pollutants: sources of inter-individual variability
Human and Experimental Toxicology, March 1, 2007; 26(3): 149 - 157.
[Abstract] [PDF]

Home page
 Toxicol SciHome page
J. B. Morris, W. S. Wilkie, and D. J. Shusterman
Acute Respiratory Responses of the Mouse to Chlorine
Toxicol. Sci., February 1, 2005; 83(2): 380 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. G. Martin, H. R. Campbell, H. Iijima, D. Gautrin, J.-L. Malo, D. H. Eidelman, Q. Hamid, and K. Maghni
Chlorine-induced Injury to the Airways in Mice
Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 568 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Nodelman and J. S. Ultman
Longitudinal distribution of chlorine absorption in human airways: a comparison to ozone absorption
J Appl Physiol, December 1, 1999; 87(6): 2073 - 2080.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online