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J Appl Physiol 86: 1959-1970, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 6, 1959-1970, June 1999

Alterations in pulmonary surfactant after rapid arousal from torpor in the marsupial Sminthopsis crassicaudata

Olga V. Lopatko1, Sandra Orgeig1, David Palmer2, Samuel Schürch2, and Christopher B. Daniels1

1 Department of Physiology, The University of Adelaide, Adelaide, South Australia 5005; and 2 Respiratory Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

Torpor in the dunnart, Sminthopsis crassicaudata, alters surfactant lipid composition and surface activity. Here we investigated changes in surfactant composition and surface activity over 1 h after rapid arousal from torpor (15-30°C at 1°C/min). We measured total phospholipid (PL), disaturated PL (DSP), and cholesterol (Chol) content of surfactant lavage and surface activity (measured at both 15 and 37°C in the captive bubble surfactometer). Immediately after arousal, Chol decreased (from 4.1 ± 0.05 to 2.8 ± 0.3 mg/g dry lung) and reached warm-active levels by 60 min after arousal. The Chol/DSP and Chol/PL ratios both decreased to warm-active levels 5 min after arousal because PL, DSP, and the DSP/PL ratio remained elevated over the 60 min after arousal. Minimal surface tension and film compressibility at 17 mN/m at 37°C both decreased 5 min after arousal, correlating with rapid changes in surfactant Chol. Therefore, changes in lipids matched changes in surface activity during the postarousal period.

phospholipids; cholesterol; surface activity; surface tension; temperature


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