Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 86: 1828-1832, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 6, 1828-1832, June 1999

Impact of hyperinsulinemia on myosin heavy chain gene regulation

Joseph A. Houmard1, D. Sean O'Neill1, Donghai Zheng2, Matthew S. Hickey1, and G. Lynis Dohm2

1 Human Performance Laboratory, Department of Exercise and Sport Science and School of Medicine, and 2 Department of Biochemistry, East Carolina University, Greenville, North Carolina 27858

The purpose of this study was to determine whether hyperinsulinemia alters myosin heavy chain (MHC) gene expression in human skeletal muscle. A biopsy from the vastus lateralis was obtained in young, lean [age 24.6 ± 1.0 (SE) yr, body fat 11.9 ± 1.9%, body mass index 26.1 ± 1.1 kg/m2; n = 10] men before and after 3 h of hyperinsulinemia (hyperinsulinemic-euglycemic clamp). Muscle was analyzed for mRNA of type I, IIa, and IIx MHC isoforms. Hyperinsulinemia (mean of 1,065.7 ± 9.8 pmol/l during minutes 20 to 180) did not change (P > 0.05) the mRNA concentration of either the type I MHC or type IIA MHC isoforms. In contrast, type IIX MHC mRNA increased (P < 0.05) with hyperinsulinemia compared with the fasted condition. These data indicate that hyperinsulinemia rapidly increases type IIx MHC mRNA in human skeletal muscle.

skeletal muscle; insulin resistance; fiber type; messenger ribonucleic acid


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