Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 1823-1827, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Azenabor, A. A.
Right arrow Articles by Hoffman-Goetz, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Azenabor, A. A.
Right arrow Articles by Hoffman-Goetz, L.
Vol. 86, Issue 6, 1823-1827, June 1999

Intrathymic and intrasplenic oxidative stress mediates thymocyte and splenocyte damage in acutely exercised mice

A. A. Azenabor and L. Hoffman-Goetz

Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1

Reactive oxygen species may contribute to apoptosis in lymphoid tissues observed after exercise. Thymic and splenic tissues excised from control mice (C) or mice immediately after (t0) or 24 h after (t24) a run to exhaustion (RTE) were assayed for biochemical indexes of oxidative stress [thymic and splenic membrane lipid peroxides, superoxide dismutase, catalase, plasma uric acid (UA), and ascorbic acid (AA)]. There were significant increases in membrane lipid peroxides in thymus (P < 0.001) and spleen (P < 0.001) in acutely exercised mice relative to controls (thymus: C = 2.74 ± 0.80 µM; t0 = 7.45 ± 0.48 µM; t24 = 9.44 ±1.41 µM; spleen: C = 0.48 ± 0.22 µM; t0 = 1.78 ± 0.28 µM; t24 = 2.81 ± 0.34 µM). The thymic and splenic tissue antioxidant enzymes concentrations of superoxide dismutase and catalase were significantly lower in samples collected at t0 relative to C and t24 mice (P < 0.001). Plasma UA and AA levels were used to assess the impact of the RTE on the peripheral antioxidant pool. There was no significant change in UA levels and a significant reduction in plasma AA concentrations (P < 0.001); the reduction in plasma AA occurred at t24 (6.53 ± 1.64 µM) relative to t0 (13.11 ± 0.71 µM) and C (13.26 ± 1.2 µM). These results suggest that oxidative damage occurs in lymphoid tissues after RTE exercise and that such damage may contribute to lymphocyte damage observed after acute exercise.

membrane lipid peroxide; superoxide dismutase; catalase; thymocytes; splenocytes


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
Z. F. Kapasi, M. L. McRae, and R. Ahmed
Suppression of viral specific primary T-cell response following intense physical exercise in young but not old mice
J Appl Physiol, February 1, 2005; 98(2): 663 - 671.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Hoffman-Goetz, J. Quadrilatero, J. Boudreau, and J. Guan
Adrenalectomy in mice does not prevent loss of intestinal lymphocytes after exercise
J Appl Physiol, June 1, 2004; 96(6): 2073 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. C. Mooren, D. Bloming, A. Lechtermann, M. M. Lerch, and K. Volker
Lymphocyte apoptosis after exhaustive and moderate exercise
J Appl Physiol, July 1, 2002; 93(1): 147 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. K. Pedersen and L. Hoffman-Goetz
Exercise and the Immune System: Regulation, Integration, and Adaptation
Physiol Rev, July 1, 2000; 80(3): 1055 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. C. Nieman, D. A. Henson, S. R. McAnulty, L. McAnulty, N. S. Swick, A. C. Utter, D. M. Vinci, S. J. Opiela, and J. D. Morrow
Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon
J Appl Physiol, May 1, 2002; 92(5): 1970 - 1977.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online