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J Appl Physiol 86: 1603-1609, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 5, 1603-1609, May 1999

Dexamethasone attenuates grain sorghum dust extract-induced increase in macromolecular efflux in vivo

Syed R. Akhter, Hiroyuki Ikezaki, Xiao-Pei Gao, and Israel Rubinstein

Department of Medicine, University of Illinois at Chicago, and West Side Department of Veterans Affairs Medical Center, Chicago, Illinois 60612

The purpose of this study was to determine whether dexamethasone attenuates grain sorghum dust extract-induced increase in macromolecular efflux from the in situ hamster cheek pouch and, if so, whether this response is specific. By using intravital microscopy, we found that an aqueous extract of grain sorghum dust elicited significant, concentration-dependent leaky site formation and increase in clearance of FITC-labeled dextran (FITC-dextran; mol mass, 70 kDa) from the in situ hamster cheek pouch (P < 0.05). This response was significantly attenuated by dexamethasone (10 mg/kg iv). Dexamethasone also attenuated substance P-induced leaky site formation and increase in clearance of FITC-dextran from the cheek pouch but had no significant effects on adenosine-induced responses. Dexamethasone had no significant effects on arteriolar diameter in the cheek pouch. On balance, these data indicate that dexamethasone attenuates grain sorghum dust extract- and substance P-induced increases in macromolecular efflux from the in situ hamster cheek pouch in a specific fashion.

microcirculation; neurogenic inflammation; venules; substance P; corticosteroids; hamster


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