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1 Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287; 2 School of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4; and 3 Clinical Neurocience Branch, Clinical Neurochemistry Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
Subjective thermal comfort plays a
critical role in body temperature regulation since this represents the
primary stimulus for behavioral thermoregulation. Although both core
(Tc) and skin-surface (Tsk) temperatures are known
afferent inputs to the thermoregulatory system, the relative
contributions of Tc and
Tsk to thermal comfort are
unknown. We independently altered
Tc and
Tsk in human subjects while
measuring thermal comfort, vasomotor changes, metabolic heat
production, and systemic catecholaminergic responses. Multiple linear
regression was used to determine the relative
Tc/Tsk
contribution to thermal comfort and the autonomic thermoregulatory
responses, by using the ratio of regression coefficients for
Tc and
Tsk. The
Tc/Tsk
contribution ratio was relatively lower for thermal comfort (1:1) than
for vasomotor changes (3:1; P = 0.008), metabolic heat production (3.6:1;
P = 0.001), norepinephrine (1.8:1;
P = 0.03), and epinephrine (3:1;
P = 0.006) responses. Thus
Tc and Tsk contribute about equally
toward thermal comfort, whereas Tc predominates in regulation of the autonomic and metabolic responses.
adrenergic; epinephrine; hypothermia; metabolism; norepinephrine; thermal comfort; thermoregulation; vasoconstriction
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