Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 86: 1578-1582, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 5, 1578-1582, May 1999

Acute mountain sickness is not related to cerebral blood flow: a decompression chamber study

Ralf W. Baumgartner1, Ioakim Spyridopoulos2, Peter Bärtsch3, Marco Maggiorini4, and Oswald Oelz4

Departments of 1 Neurology and 4 Internal Medicine, University Hospital, CH-8091 Zürich, Switzerland; 2 Department of Internal Medicine III, Eberhard-Karls-University, 72070 Tübingen; and 3 Department of Internal Medicine, Division of Sports Medicine, University of Heidelberg, 69115 Heidelberg, Germany

To evaluate the pathogenetic role of cerebral blood flow (CBF) changes occurring before and during the development of acute mountain sickness (AMS), peak mean middle cerebral artery flow velocities (<OVL><IT>V</IT></OVL><SUB>MCA</SUB>) were assessed by transcranial Doppler sonography in 10 subjects at 490-m altitude, and during three 12-min periods immediately (SA1), 3 (SA2), and 6 (SA3) h after decompression to a simulated altitude of 4,559 m. AMS cerebral scores increased from 0.16 ± 0.14 at baseline to 0.44 ± 0.31 at SA1, 1.11 ± 0.88 at SA2 (P < 0.05), and 1.43 ± 1.03 at SA3 (P < 0.01); correspondingly, three, seven, and eight subjects had AMS. Absolute and relative <OVL><IT>V</IT></OVL><SUB>MCA</SUB> at simulated altitude, expressed as percentages of low-altitude values (%<OVL><IT>V</IT></OVL><SUB>MCA</SUB>), did not correlate with AMS cerebral scores. Average %<OVL><IT>V</IT></OVL><SUB>MCA</SUB> remained unchanged, because %<OVL><IT>V</IT></OVL><SUB>MCA</SUB> increased in three and remained unchanged or decreased in seven subjects at SA2 and SA3. These results suggest that CBF is not important in the pathogenesis of AMS and shows substantial interindividual differences during the first hours at simulated altitude.

altitude illness; cerebral hemodynamics; ultrasonics


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