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Departments of 1 Otolaryngology and 2 Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
Previous
experiments in anesthetized or decerebrate cats showed that the
vestibular system participates in adjusting blood pressure during
postural changes. The present experiments tested the hypothesis that
removal of vestibular inputs in awake cats would affect orthostatic
tolerance. Before the lesion, blood pressure typically remained within
10 mmHg of baseline values during nose-up-pitch body rotations of up to
60° in amplitude. In contrast, bilateral peripheral vestibular
lesions altered the pattern of orthostatic responses in all animals,
and blood pressure fluctuated >10 mmHg from baseline values during
most 60° nose-up tilts in five of six animals. The deficit in
correcting blood pressure was particularly large when the animal also
was deprived of visual cues indicating position in space. During this
testing condition, either a decrease or increase in blood pressure
>10 mmHg in magnitude occurred in >80% of tilts. The deficit in
adjusting blood pressure after vestibular lesions persisted for only 1 wk, after which time blood pressure remained stable during tilt. These
data show that removal of vestibular inputs alters orthostatic
responses and are consistent with the hypothesis that vestibular
signals are one of several inputs that are integrated to elicit
compensatory changes in blood pressure during movement.
blood pressure; heart rate; cardiovascular system; exercise
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