Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 1497-1504, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Padnick, L. B.
Right arrow Articles by Goldstick, T. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Padnick, L. B.
Right arrow Articles by Goldstick, T. K.
Vol. 86, Issue 5, 1497-1504, May 1999

Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex

Lissa B. Padnick1, Robert A. Linsenmeier1,3,4, and Thomas K. Goldstick1,2,3,4

Departments of 1 Biomedical Engineering, 2 Chemical Engineering, and 3 Neurobiology and Physiology, and 4 Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208-3107

Tissue PO2 was measured in the primary visual cortex of anesthetized, artificially ventilated, normovolemic cats to evaluate the effect of small doses [1 g perfluorocarbon (PFC)/kg] of a PFC emulsion (1 g PFC/1.1 ml emulsion; Alliance Pharmaceutical, San Diego, CA) on brain oxygenation. The change in tissue PO2 (Delta PO2), resulting from briefly changing the respiratory gas from room air to 100% oxygen, was measured before and after intravenous infusion of the emulsion. Before emulsion, Delta PO2 was 51.1 ± 45.6 Torr (n = 8 cats). Increases in Delta PO2 of 34.0 ± 26.1 (SD) % (n = 8) and 16.3 ± 8.4% (n = 6) were observed after the first and second emulsion infusions, respectively. The further increase in Delta PO2 after the third dose (7.9 ± 10.5%; n = 7) was not statistically significant. The observed increases in tissue oxygenation as a result of the PFC infusions appear to be the result of enhanced oxygen transport to the tissue.

tissue oxygen tension; brain


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
B. D. Spiess
Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics
J Appl Physiol, April 1, 2009; 106(4): 1444 - 1452.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online