Journal of Applied Physiology
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J Appl Physiol 86: 1490-1496, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 5, 1490-1496, May 1999

Oxygenation of the cat primary visual cortex

Lissa B. Padnick1, Robert A. Linsenmeier1,3,4, and Thomas K. Goldstick1,2,3,4

Departments of 1 Biomedical Engineering, 2 Chemical Engineering, and 3 Neurobiology and Physiology, and 4 Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208-3107

Tissue PO2 was measured in the primary visual cortex of anesthetized, artificially ventilated normovolemic cats to examine tissue oxygenation with respect to depth. The method utilized 1) a chamber designed to maintain cerebrospinal fluid pressure and prevent ambient PO2 from influencing the brain, 2) a microelectrode capable of recording electrical activity as well as local PO2, and 3) recordings primarily during electrode withdrawal from the cortex rather than during penetrations. Local peaks in the PO2 profiles were consistent with the presence of numerous vessels. Excluding the superficial 200 µm of the cortex, in which the ambient PO2 may have influenced tissue PO2, there was a slight decrease (4.9 Torr/mm cortex) in PO2 as a function of depth. After all depths and cats were weighted equally, the average PO2 in six cats was 12.8 Torr, with approximately one-half of the values being <= 10 Torr. The kurtosis of the PO2 histogram, with all depths and cats weighted equally, was 3.61, and the skewness was 1.70.

intracortical oxygen tension; brain


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