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1 Geriatric Research,
Local warming of
skin induces vasodilation by unknown mechanisms. To test whether nitric
oxide (NO) is involved, we examined effects of NO synthase (NOS)
inhibition with
NG-nitro-L-arginine
methyl ester (L-NAME) on
vasodilation induced by local warming of skin in six subjects. Two
adjacent sites on the forearm were instrumented with intradermal
microdialysis probes for delivery of
L-NAME and sodium
nitroprusside. Skin blood flow was monitored by
laser-Doppler flowmetry (LDF) at microdialysis sites. Local temperature
(Tloc) of the skin at both sites
was controlled with special LDF probe holders. Mean arterial pressure (MAP; Finapres) was measured and cutaneous vascular conductance calculated (CVC = LDF/MAP = mV/mmHg). Data collection began with a
control period (Tloc at both sites = 34°C). One site was then warmed to 41°C while the second was
maintained at 34°C. Local warming increased CVC from 1.44 ± 0.41 to 4.28 ± 0.60 mV/mmHg (P < 0.05). Subsequent L-NAME
administration reduced CVC to 2.28 ± 0.47 mV/mmHg
(P < 0.05 vs. heating), despite the
continued elevation of Tloc. At a
Tloc of 34°C,
L-NAME reduced CVC from 1.17 ± 0.23 to 0.75 ± 0.11 mV/mmHg
(P < 0.05). Administration of sodium
nitroprusside increased CVC to levels no different from those induced
by local warming. Thus NOS inhibition attenuated, and sodium
nitroprusside restored, the cutaneous vasodilation induced by elevation
of Tloc; therefore, the mechanism
of cutaneous vasodilation by local warming requires NOS generation of NO.
skin blood flow; skin temperature; vasodilation; laser-Doppler flowmetry; microdialysis
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