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J Appl Physiol 86: 1151-1159, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 4, 1151-1159, April 1999

Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep

Hiroyuki Sakurai1, Frank C. Schmalstieg2, Lillian D. Traber3, Hal K. Hawkins4, and Daniel L. Traber3

1 Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical College, Tokyo, Japan; and Departments of 2 Pediatrics, 3 Anesthesiology and Physiology and Biophysics, and 4 Pathology, The University of Texas Medical Branch, and Shriners Burns Institute, Galveston Texas 77555-0823

The effects of a monoclonal antibody against L-selectin [leukoctye adhesion molecule (LAM)1-3] on microvascular fluid flux were determined in conscious sheep subjected to a combined injury of 40% third-degree burn and smoke inhalation. This combined injury induced a rapid increase in systemic prefemoral lymph flow (sQlymph) from the burned area and a delayed-onset increase in lung lymph flow. The initial increase in sQlymph was associated with an elevation of the lymph-to-plasma oncotic pressure ratio; consequently, it leads to a predominant increase in the systemic soft tissue permeability index (sPI). In an untreated control group, the increased sPI was sustained beyond 24 h after injury. Pretreatment with LAM1-3 resulted in earlier recovery from the increased sPI, although the initial responses in sQlymph and sPI were identical to those in the nontreatment group. The delayed-onset lung permeability changes were significantly attenuated by pretreatment with LAM1-3. These findings indicate that both leukocyte-dependent and -independent mechanisms are involved in the pathogenesis that occurs after combined injury with burn and smoke inhalation.

systemic prefemoral lymph; lung lymph; fluid balance; hemodynamics; sheep


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