Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 860-866, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hutter, J.
Right arrow Articles by Messmer, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hutter, J.
Right arrow Articles by Messmer, K.
Vol. 86, Issue 3, 860-866, March 1999

Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle

Jörg Hutter1, Oliver Habler1,2, Martin Kleen2, Matthias Tiede1, Armin Podtschaske1, Gregor Kemming2, Carlos Corso1, Sanjay Batra3, Peter Keipert3, Simon Faithfull3, and Konrad Messmer1

1 Institute for Surgical Research and 2 Institute of Anesthesiology, Klinikum Grosshadern, University of Munich, 81366 Munich, Germany; and 3 Alliance Pharmaceutical Corporation, San Diego, California 92121

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 ± 3 to 20 ± 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 ± 0.79 vs. 4.79 ± 0.73 l · min-1 · m-2) and muscle perfusion (4.07 ± 0.44 vs. 5.18 ± 0.36 ml · 100 g-1 · min-1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 ± 0.06 vs. 0.48 ± 0.03 ml O2 · 100 g-1 · min-1). Nevertheless, tissue PO2 was preserved (27.4 ± 1.3 vs. 29.9 ± 1.4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 ± 2.2 vs. 13.9 ± 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.

heterogeneity of perfusion; oxygen transport; dog; acute normovolemic hemodilution


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. C. W. Hsia, R. L. Johnson Jr., D. M. Dane, E. Y. Wu, A. S. Estrera, H. E. Wagner, and P. D. Wagner
The canine spleen in oxygen transport: gas exchange and hemodynamic responses to splenectomy
J Appl Physiol, November 1, 2007; 103(5): 1496 - 1505.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. A. Dahaba, S. I. Perelman, D. M. Moskowitz, H. L. Bennett, A. Shander, K. Oettl, G. Reibnegger, and H. Metzler
Influence of acute normovolaemic haemodilution on the dose-response relationship, time-course of action and pharmacokinetics of rocuronium bromide
Br. J. Anaesth., October 1, 2006; 97(4): 482 - 488.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Dane, C. C. W. Hsia, E. Y. Wu, R. T. Hogg, D. C. Hogg, A. S. Estrera, and R. L. Johnson Jr.
Splenectomy impairs diffusive oxygen transport in the lung of dogs
J Appl Physiol, July 1, 2006; 101(1): 289 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. J. Pearce, C. Waasdorp, H. Hufnagel, D. Burris, J. DeFeo, P. Soballe, and W. R. Drucker
Subcutaneous PO2 as an index of the physiological limits for hemodilution in the rat
J Appl Physiol, September 1, 2005; 99(3): 814 - 821.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. A. Schwarte, A. Fournell, J. van Bommel, and C. Ince
Redistribution of intestinal microcirculatory oxygenation during acute hemodilution in pigs
J Appl Physiol, March 1, 2005; 98(3): 1070 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. J. McKenzie, S. Wong, D. J. Randall, S. Egginton, E. W. Taylor, and A. P. Farrell
The effects of sustained exercise and hypoxia upon oxygen tensions in the red muscle of rainbow trout
J. Exp. Biol., October 1, 2004; 207(21): 3629 - 3637.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. Rochon, A. Caron, M. Toussaint-Hacquard, A. I. Alayash, M. Gentils, P. Labrude, J. F. Stoltz, and P. Menu
Hemodilution With Stoma-Free Hemoglobin at Physiologically Maintained Viscosity Delays the Onset of Vasoconstriction
Hypertension, May 1, 2004; 43(5): 1110 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Creteur, Q. Sun, O. Abid, D. De Backer, P. Van Der Linden, and J.-L. Vincent
Normovolemic hemodilution improves oxygen extraction capabilities in endotoxic shock
J Appl Physiol, October 1, 2001; 91(4): 1701 - 1707.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online