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1 The Copenhagen Muscle
Research Center, and Departments of
3 Neurology,
4 Clinical Physiology, and
5 Anesthesia,
To localize a
central nervous feed-forward mechanism involved in cardiovascular
regulation during exercise, brain activation patterns were measured in
eight subjects by employing positron emission tomography and
oxygen-15-labeled water. Scans were performed at rest and
during rhythmic handgrip before and after axillary blockade with
bupivacaine. After the blockade, handgrip strength was reduced to 25%
(range 0-50%) of control values, whereas handgrip-induced heart
rate and blood pressure increases were unaffected (13 ± 3 beats/min
and 12 ± 5 mmHg, respectively; means ± SE). Before regional
anesthesia, handgrip caused increased activation in the contralateral
sensory motor area, the supplementary motor area, and the ipsilateral
cerebellum. We found no evidence for changes in the activation pattern
due to an interaction between handgrip and regional anesthesia. This
was true for both the blocked and unblocked arm. It remains unclear
whether the activated areas are responsible for the increase in
cardiovascular variables, but neural feedback from the contracting
muscles was not necessary for the activation in the mentioned areas
during rhythmic handgrip.
brain; exercise; positron emission tomography; oxygen-15- labeled water
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