Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 86: 1075-1080, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 3, 1075-1080, March 1999

SPECIAL COMMUNICATION
LMR spectroscopy: a new sensitive method for on-line recording of nitric oxide in breath

Petra Mürtz1, Lars Menzel1, Wilhelm Bloch2, Alexander Hess3, Olaf Michel3, and Wolfgang Urban1

1 Institut für Angewandte Physik der Universität Bonn, D-53115 Bonn; and 2 Anatomisches Institut I and 3 Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde der Universität Köln, D-50931 Cologne, Germany

Laser magnetic resonance spectroscopy (LMRS) is a sensitive and isotope-selective technique for determining low concentrations of gaseous free radicals with high time resolution. We used this technique to analyze the nitric oxide (NO) concentration profile while simultaneously measuring the flow and expired volume during several single breathing cycles. Eight healthy, nonallergic volunteers were investigated. An initial NO peak was found in all breathing cycles before the NO concentration dropped to a relatively stable plateau in the late phase of expiration. The nasal NO peak was significantly higher than the oral NO peak. The nasal NO plateau was always higher than the oral NO plateau. The height of the initial nasal and oral NO peak rose with increasing duration of breath hold, whereas the late expiratory NO plateau changed only little for either the nasal or the oral breathing cycles. Our findings demonstrate, in line with other reports using other techniques, that the nose is the primary source for NO within the airways.

laser magnetic resonance; nitric oxide concentration; exhaled air; nitric oxide synthase


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