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1 Sections of Cardiology and
2 Pulmonary,
We examined muscle sympathetic nerve activity (MSNA) in the
nonexercising lower limb during repetitive static quadriceps
contraction paradigm at 25% maximal voluntary contraction in eight
men. Subjects performed 20-s contractions with 5-s rest periods for up
to 12 contractions. Although the workload was constant, we found that MSNA amplitude rose as a function of contraction number [0.6 ln (amplitude/min)/contraction]; this suggests chemical
sensitization of the muscle reflex response. We employed
signal-averaging techniques and then integrated the data to examine the
onset latency of the MSNA response as a function of the 25-s
contraction-rest period. We observed an onset latency of ~4-6 s.
Moreover, although the onset latency did not appear to vary as a
function of contraction number, the rate of MSNA increase took
approximately four contractions to reach a steady-state rate of rise;
this suggests contraction-induced sensitization. The onset latency
reported here is similar to findings in recent animal studies, but it
is at odds with latencies determined in prior human handgrip
contraction studies. We believe our data suggest that
1) mechanically sensitive afferents
contribute importantly to the MSNA response to the paradigm employed
and 2) these afferents may be
sensitized by the chemical products of muscle contraction.
sympathetic nerve activity; autonomic reflexes; exercise; muscle reflexes
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