| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Radiology, Royal Brompton Hospital, London SW3 6NP; 2 Department of Respiratory Medicine, Green Lane Hospital, Auckland, New Zealand; and 3 Clinical Studies Unit, National Heart and Lung Institute, London SW3 6LY, United Kingdom
The purpose of this study was to investigate
whether hypoxic pulmonary vasoconstriction is the major determinant of
the computed tomography (CT) pattern of mosaic attenuation in asthmatic
patients with induced bronchoconstriction. Thin-section CT was
performed at suspended full inspiration immediately and 30 min after
methacholine bronchoprovocation in 22 asthmatic subjects, who were
randomly assigned to breathe room air (group A,
n = 8), oxygen via nasal prongs at 5 l/min (group B,
n = 8), and oxygen via face mask at 12 l/min (group C,
n = 6). CT changes were quantified in
terms of global lung density and density in hypodense and hyperdense areas. Lung parenchymal density increases were greatest in
group C and greater in
group B than in group
A, globally (P = 0.03) and in hypodense regions (P = 0.01).
On bivariate analysis, the only change in cross-sectional area was
related to change in global density. In hypodense regions, density
change was related both to reduction in cross-sectional area
(P < 0.0005) and to oxygen administration (P = 0.01). After
correction for changes in global lung density, only oxygen was
independently related to density increase in hypodense areas
(P = 0.02). In induced
bronchoconstriction, the CT appearance of mosaic attenuation can be
largely ascribed to hypoxic vasoconstriction rather than to changes in
lung inflation.
hypoxic pulmonary vasoconstriction; computed tomography of the lung; functional computed tomography
This article has been cited by other articles:
|
|
 |
|
  D. A. Kaminsky, C. G. Irvin, L. K. A. Lundblad, J. Thompson-Figueroa, J. Klein, M. J. Sullivan, F. Flynn, S. Lang, L. Bourassa, S. Burns, et al. Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine J Appl Physiol, January 1, 2008; 104(1): 10 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Suga, Y. Kawakami, H. Iwanaga, O. Tokuda, and N. Matsunaga Automated Breath-Hold Perfusion SPECT/CT Fusion Images of the Lungs Am. J. Roentgenol., August 1, 2007; 189(2): 455 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. D. Knollmann, R. Ewert, T. Wundrich, R. Hetzer, and R. Felix Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients: Use of Spirometrically Gated CT Radiology, December 1, 2002; 225(3): 655 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.M. Hansell Small airways diseases: detection and insights with computed tomography Eur. Respir. J., June 1, 2001; 17(6): 1294 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H R Roberts, A U Wells, D G Milne, M B Rubens, J Kolbe, P J Cole, and D M Hansell Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests Thorax, March 1, 2000; 55(3): 198 - 204. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
