| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Noll Physiological Research Center, Pennylvania State University, University Park, Pennsylvania 16802-6900; and 2 Division of Life Sciences, Rutgers, State University of New Jersey, Piscataway, New Jersey 08855
Exercise, salt
restriction, and/or dehydration causes transient reductions in
renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose
of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a
placebo (Pl) in humans subjected to progressive renal stresses. After
baseline measurements, 12 fit young (25 ± 1 yr) men and women
underwent 3 days of a low (10 meq/day)-sodium diet while taking one of
the drugs or Pl (crossover design). Day
4 involved dehydration (
1.6% body wt) followed
by 45 min of treadmill exercise (65% maximal
O2 uptake) in the heat (36°C).
These combined stressors caused dramatic decreases in effective renal
plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118-123 ml/min) decreased to 78 ± 4, 73 ± 5, and 82 ± 5 ml/min postexercise in the Acet, Ibu, and Pl
trials, respectively, with a significantly greater decrease in GFR in the Ibu trial (P < 0.05 vs. Pl). OTC
Ibu has small but statistically significant effects on GFR during
exercise in a sodium- and volume-depleted state; OTC Acet was
associated with no such effects.
exercise; prostaglandins; plasma renin activity; glomerular filtration rate; renal hemodynamics; nonsteroidal anti-inflammatory drugs
This article has been cited by other articles:
|
|
 |
|
  K. Knobloch, P. M. Vogt, R. H. Brophy, S. A. Rodeo, and R. F. Warren Letter to the Editor * Authors' Response Am. J. Sports Med., July 1, 2008; 36(7): e2 - e3. [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Leshnower, H. Sakamoto, A. Zeeshan, L. M. Parish, R. Hinmon, T. Plappert, B. M. Jackson, J. H. Gorman III, and R. C. Gorman Role of acetaminophen in acute myocardial infarction Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2424 - H2431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lahtinen, H. Kokki, H. Hendolin, T. Hakala, and M. Hynynen Propacetamol as Adjunctive Treatment for Postoperative Pain After Cardiac Surgery Anesth. Analg., October 1, 2002; 95(4): 813 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Merrill Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1341 - H1349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hyllested, S. Jones, J. L. Pedersen, and H. Kehlet Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review Br. J. Anaesth., February 1, 2002; 88(2): 199 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. PERINOTTO, A. BIGGI, N. CARRA, A. ORRICO, G. VALMADRE, P. DALL'AGLIO, A. NOVARINI, and A. MONTANARI Angiotensin II and Prostaglandin Interactions on Systemic and Renal Effects of L-NAME in Humans J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1706 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. B. Farquhar and W. L. Kenney Age and renal prostaglandin inhibition during exercise and heat stress J Appl Physiol, June 1, 1999; 86(6): 1936 - 1943. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
