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1 Noll Physiological Research Center, Pennylvania State University, University Park, Pennsylvania 16802-6900; and 2 Division of Life Sciences, Rutgers, State University of New Jersey, Piscataway, New Jersey 08855
Exercise, salt
restriction, and/or dehydration causes transient reductions in
renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose
of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a
placebo (Pl) in humans subjected to progressive renal stresses. After
baseline measurements, 12 fit young (25 ± 1 yr) men and women
underwent 3 days of a low (10 meq/day)-sodium diet while taking one of
the drugs or Pl (crossover design). Day
4 involved dehydration (
1.6% body wt) followed
by 45 min of treadmill exercise (65% maximal
O2 uptake) in the heat (36°C).
These combined stressors caused dramatic decreases in effective renal
plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118-123 ml/min) decreased to 78 ± 4, 73 ± 5, and 82 ± 5 ml/min postexercise in the Acet, Ibu, and Pl
trials, respectively, with a significantly greater decrease in GFR in the Ibu trial (P < 0.05 vs. Pl). OTC
Ibu has small but statistically significant effects on GFR during
exercise in a sodium- and volume-depleted state; OTC Acet was
associated with no such effects.
exercise; prostaglandins; plasma renin activity; glomerular filtration rate; renal hemodynamics; nonsteroidal anti-inflammatory drugs
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