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J Appl Physiol 86: 564-568, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 2, 564-568, February 1999

Rat hindlimb muscle blood flow during level and downhill locomotion

Michael D. Delp1, Changping Duan2, Chester A. Ray3, and R. B. Armstrong1

1 Departments of Health and Kinesiology and Medical Physiology, Texas A&M University, College Station, Texas 77843; 2 Department of Surgery, Allegheny University of the Health Sciences, Pittsburgh Campus, Pittsburgh, Pennsylvania 15212; and 3 Departments of Medicine and Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033

During eccentrically biased exercise (e.g., downhill locomotion), whole body oxygen consumption and blood lactate concentrations are lower than during level locomotion. These general systemic measurements indicate that muscle metabolism is lower during downhill exercise. This study was designed to test the hypothesis that hindlimb muscle blood flow is correspondingly lower during downhill vs. level exercise. Muscle blood flow (determined by using radioactive microspheres) was measured in rats after 15 min of treadmill exercise at 15 m/min on the level (L, 0°) or downhill (D, -17°). Blood flow to ankle extensor muscles was either lower (e.g., white gastrocnemius muscle: D, 9 ± 2; L, 15 ± 1 ml · min-1 · 100 g-1) or not different (e.g., soleus muscle: D, 250 ± 35; L, 230 ± 21 ml · min-1 · 100 g-1) in downhill vs. level exercise. In contrast, blood flow to ankle flexor muscles was higher (e.g., extensor digitorum longus muscle: D, 53 ± 5; L, 31 ± 6 ml · min-1 · 100 g-1) during downhill vs. level exercise. When individual extensor and flexor muscle flows were summed, total flow to the leg was lower during downhill exercise (D, 3.24 ± 0.08; L, 3.47 ± 0.05 ml/min). These data indicate that muscle blood flow and metabolism are lower during eccentrically biased exercise but are not uniformly reduced in all active muscles; i.e., flows are equivalent in several ankle extensor muscles and higher in ankle flexor muscles.

concentric contraction; eccentric contraction; muscle temperature


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