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J Appl Physiol 86: 469-473, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 2, 469-473, February 1999

Endogenous vasopressin does not mediate hypoxia-induced anapyrexia in rats

Alexandre A. Steiner1, Evelin C. Carnio2, José Antunes-Rodrigues3, and Luiz G. S. Branco1

1 Faculdade de Odontologia de Ribeirão Preto, 2 Escola de Enfermagem de Ribeirão Preto, and 3 Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14040-904 Ribeirão Preto, São Paulo, Brazil

The present study was designed to test the hypothesis that arginine vasopressin (AVP) mediates hypoxia-induced anapyrexia. The rectal temperature of awake, unrestrained rats was measured before and after hypoxic hypoxia, AVP-blocker injection, or a combination of the two. Control animals received saline injections of the same volume. Basal body temperature was 36.52 ± 0.29°C. We observed a significant (P < 0.05) reduction in body temperature of 1.45 ± 0.33°C after hypoxia (7% inspired O2), whereas systemic and central injections of AVP V1- and AVP V2-receptor blockers caused no change in body temperature. When intravenous injection of AVP blockers was combined with hypoxia, we observed a reduction in body temperature of 1.49 ± 0.41°C (V1-receptor blocker) and of 1.30 ± 0.13°C (V2-receptor blocker), similar to that obtained by application of hypoxia only. Similar results were observed when the blockers were injected intracerebroventricularly. The data indicate that endogenous AVP does not mediate hypoxia-induced anapyrexia in rats.

temperature; hypothermia


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A. A. Steiner, E. C. Carnio, and L. G. S. Branco
Role of neuronal nitric oxide synthase in hypoxia-induced anapyrexia in rats
J Appl Physiol, September 1, 2000; 89(3): 1131 - 1136.
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