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J Appl Physiol 86: 461-468, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 2, 461-468, February 1999

Effects of eccentric exercise on the immune system in men

Christer Malm1, Rodica Lenkei2, and Bertil Sjödin3

1 Department of Physiology and Pharmacology, Karolinska Institute, S-114 86 Stockholm; 2 Centrala Automations Laboratoriet, St. Görans Hospital, S-112 81 Stockholm; and 3 Swedish National Research Establishment, S-172 90 Stockholm, Sweden

The effects of eccentric exercise on changes in numbers of circulating leukocytes, cell activation, cell adhesion, and cellular memory function were investigated in 12 men, aged 22-35 yr. The immunologic effects of postexercise epidermal treatment with monochromatic, infrared light were also evaluated. Blood was drawn before and 6, 24, and 48 h after exercise for phenotyping and analysis of creatine kinase activity. There was an increase in leukocyte, monocyte, and neutrophil number, no change in the number of basophils, eosinophils, B cells, and T cells, and a decrease in natural killer cell number postexercise. Some markers of lymphocyte and monocyte activation remained unchanged or decreased, whereas the expression of adhesion molecules 62L and 11b increased on monocytes. It is concluded that eccentric exercise induced decreased activation, and increased cell adhesion capacity, of monocytes. Altered trafficking of cells between lymphoid tissue and blood, selective apoptosis, or attachment/detachment from the endothelial wall can explain the observed phenotypic changes. Treatment with monochromatic, infrared light did not significantly affect any of the investigated variables. Correlations between immunologic and physiological parameters indicate a role of the immune system in adaptation to physical exercise.

leukocytes; muscle damage; cell adhesion; cell activation; flow cytometry


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