Journal of Applied Physiology
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J Appl Physiol 86: 450-454, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 2, 450-454, February 1999

Effect of short-term training on mitochondrial ATP production rate in human skeletal muscle

Emma C. Starritt1, Damien Angus1, and Mark Hargreaves1,2

1 Department of Physiology, The University of Melbourne, Parkville 3052; and 2 School of Health Sciences, Deakin University, Burwood 3125, Australia

Seven untrained volunteers [3 men, 4 women, 20.1 ± 2.0 (SD) yr, 66.0 ± 11.0 kg, 171 ± 13 cm] participated in a 10-day cycle exercise training program. Resting muscle samples were obtained from vastus lateralis before and after 5 and 10 days of training. Mitochondrial ATP production rate (MAPR) was assayed in isolated mitochondria by using a bioluminescence technique and referenced to the activity of glutamate dehydrogenase in the muscle sample. MAPR increased 136 and 161% after 10 days of training for the mitochondrial substrate combinations pyruvate + palmitoyl-L-carnitine + alpha -ketoglutarate + malate and palmitoyl-L-carnitine + malate, respectively. Total muscle glutamate dehydrogenase and citrate synthase activity increased 53 and 16%, respectively, after 5 days but did not significantly increase further after 10 days. The results from the present study indicate that MAPR, measured by using the substrate combinations pyruvate + palmitoyl-L-carnitine + alpha -ketoglutarate + malate and palmitoyl-L-carnitine + malate, can rapidly increase in response to endurance training.

adenosine 5'-triphosphate production rate; luminescence


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