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Departments of Medical Physiology and Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211
Our goals were to
determine the nature of endothelium-dependent and -independent vascular
responses in isolated soleus feed arteries (SFA) and to test the
hypothesis that these responses would be altered by exercise training.
Exercise-trained rats ran 30 m/min, up a 15% grade, 1 h/day, 5 days/wk
for 10-12 wk, while sedentary control rats were confined to normal
cage activity. SFA were isolated, cannulated, and pressurized at 90 cmH2O. After a 1-h equilibration
period, the dose-response relationships to constrictors,
endothelium-dependent dilators, and endothelium-independent dilators
were examined. SFA developed spontaneous tone, demonstrated myogenic
reactivity by maintaining vessel diameter in the face of large changes
in intraluminal pressure, and constricted in a dose-dependent manner to
norepinephrine and potassium chloride. SFA dilated in a dose-dependent
manner to the endothelium-dependent dilators acetylcholine and
increased flow and to the endothelium-independent dilator sodium
nitroprusside. SFA did not dilate to the putative endothelium-dependent
dilators bradykinin, substance P, and clonidine or to adenosine.
Dilation to acetylcholine was attenuated markedly by arginine analogs
and less by 20 mM KCl, but it was unaltered by indomethacin. These
results indicate that SFA respond to a number of vasoactive substances,
consistent with the hypothesis that SFA participate in the control of
vascular resistance. However, exercise training does not appear to
elicit a stimulus adequate to alter vasomotor responses in SFA.
vascular smooth muscle; endothelium; microcirculation; acetylcholine; norepinephrine
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