Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 93-100, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hopkins, S. R.
Right arrow Articles by McKirnan, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hopkins, S. R.
Right arrow Articles by McKirnan, M. D.
Vol. 86, Issue 1, 93-100, January 1999

Pulmonary gas exchange during exercise in pigs

S. R. Hopkins1, C. M. Stary1, E. Falor2, H. Wagner1, P. D. Wagner1, and M. D. McKirnan2

Departments of 1 Medicine and 2 Pathology, University of California San Diego, La Jolla, California 92093-0623

Increased ventilation-perfusion (VA/Q) inequality is observed in ~50% of humans during heavy exercise and contributes to the widening of the alveolar-arterial O2 difference (A-aDO2). Despite extensive investigation, the cause remains unknown. As a first step to more direct examination of this problem, we developed an animal model. Eight Yucatan miniswine were studied at rest and during treadmill exercise at ~30, 50, and 85% of maximal O2 consumption (VO2 max). Multiple inert-gas, blood-gas, and metabolic data were obtained. The A-aDO2 increased from 0 ± 3 (SE) Torr at rest to 14 ± 2 Torr during the heaviest exercise level, but arterial PO2 (PaO2) remained at resting levels during exercise. There was normal VA/Q inequality [log SD of the perfusion distribution (logSD<SUB><A><AC>Q</AC><AC>˙</AC></A></SUB>) = 0.42 ± 0.04] at rest, and moderate increases (logSD<SUB><A><AC>Q</AC><AC>˙</AC></A></SUB> = 0.68 ± 0.04, P < 0.0001) were observed with exercise. This result was reproducible on a separate day. The VA/Q inequality changes are similar to those reported in highly trained humans. However, in swine, unlike in humans, there was no inert gas evidence for pulmonary end-capillary diffusion limitation during heavy exercise; there was no systematic difference in the measured PaO2 and the PaO2 as predicted from the inert gases. These data suggest that the pig animal model is well suited for studying the mechanism of exercise-induced VA/Q inequality.

swine; animal model; ventilation-perfusion inequality; pulmonary diffusion limitation; interstitial pulmonary edema


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. R. Hopkins, A. Kleinsasser, S. Bernard, A. Loeckinger, E. Falor, B. Neradilek, N. L. Polissar, and M. P. Hlastala
Hypoxia has a greater effect than exercise on the redistribution of pulmonary blood flow in swine
J Appl Physiol, December 1, 2007; 103(6): 2112 - 2119.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. I. Batchinsky, W. B. Weiss, B. S. Jordan, E. J. Dick Jr., D. A. Cancelada, and L. C. Cancio
Ventilation-perfusion relationships following experimental pulmonary contusion
J Appl Physiol, September 1, 2007; 103(3): 895 - 902.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Merkus, B. Houweling, A. Zarbanoui, and D. J. Duncker
Interaction between prostanoids and nitric oxide in regulation of systemic, pulmonary, and coronary vascular tone in exercising swine
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1114 - H1123.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt, F. L. Powell, and S. R. Hopkins
Ventilation-perfusion inequality during normoxic and hypoxic exercise in the emu
J Appl Physiol, December 1, 2002; 93(6): 1980 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. Loeckinger, A. Kleinsasser, C. Keller, A. Schaefer, C. Kolbitsch, K. H. Lindner, and A. Benzer
Administration of Oxygen Before Tracheal Extubation Worsens Gas Exchange After General Anesthesia in a Pig Model
Anesth. Analg., December 1, 2002; 95(6): 1772 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Kleinsasser, K. H. Lindner, A. Schaefer, and A. Loeckinger
Decompression-Triggered Positive-Pressure Ventilation During Cardiopulmonary Resuscitation Improves Pulmonary Gas Exchange and Oxygen Uptake
Circulation, July 16, 2002; 106(3): 373 - 378.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson and M. H. Laughlin
Chronic exercise training does not alter pulmonary vasorelaxation in normal pigs
J Appl Physiol, June 1, 2000; 88(6): 2008 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson, J. L. Parker, and M. H. Laughlin
Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs
J Appl Physiol, February 1, 2000; 88(2): 443 - 451.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Dempsey and P. D. Wagner
Exercise-induced arterial hypoxemia
J Appl Physiol, December 1, 1999; 87(6): 1997 - 2006.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online