Journal of Applied Physiology
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J Appl Physiol 86: 326-334, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 1, 326-334, January 1999

Analytic calculation of physiological acid-base parameters in plasma

E. Wrenn Wooten

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232

Analytic expressions for plasma total titratable base, base excess (Delta CB), strong-ion difference, change in strong-ion difference (Delta SID), change in Van Slyke standard bicarbonate (Delta VSSB), anion gap, and change in anion gap are derived as a function of pH, total buffer ion concentration, and conditional molar equilibrium constants. The behavior of these various parameters under respiratory and metabolic acid-base disturbances for constant and variable buffer ion concentrations is considered. For constant noncarbonate buffer concentrations, Delta SID = Delta CB = Delta VSSB, whereas these equalities no longer hold under changes in noncarbonate buffer concentration. The equivalence is restored if the reference state is changed to include the new buffer concentrations.

acidosis; alkalosis; base excess; strong-ion difference; anion gap; delta anion gap


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