Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 313-319, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitchell, P.
Right arrow Articles by Hannon, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mitchell, P.
Right arrow Articles by Hannon, K.
Vol. 86, Issue 1, 313-319, January 1999

Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy

Pamela Mitchell, Tom Steenstrup, and Kevin Hannon

Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907

The potential role of the fibroblast growth factor (FGF) family during stretch-induced postnatal skeletal muscle hypertrophy was analyzed by using an avian wing-weighting model. After 2 or 11 days of weighted stretch, anterior latissimus dorsi (ALD) muscles were, on average, 34 (P < 0.01) and 85% (P < 0.01) larger, respectively, than unweighted ALD control muscles. By using quantitative RT-PCR, FGF-1 mRNA expression was found to be significantly decreased in ALD muscles stretched for 2 or 11 days. In contrast, FGF-4 and FGF-10 mRNA expression was significantly increased 2 days after initiation of stretch. FGF-2, FGF-10, fibroblast growth factor receptor 1, and FREK mRNA expression was significantly increased at 11 days poststretch. Increases in FGF-2 and FGF-4 protein could be detected throughout the myofiber periphery after 11 days of stretch. On a cellular level, FGF-2 and FGF-4 proteins were differentially localized. This differential expression pattern and protein localization of the FGF family in response to stretch-induced hypertrophy suggest distinct roles for individual FGFs during the postnatal hypertrophy process.

chicken; growth; development; reverse transcription-polymerase chain reaction; ribonucleic acid


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Tatsumi, X. Liu, A. Pulido, M. Morales, T. Sakata, S. Dial, A. Hattori, Y. Ikeuchi, and R. E. Allen
Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor
Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1487 - C1494.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Fluck, M. Kitzmann, C. Dapp, M. Chiquet, F. W. Booth, and A. Fernandez
Transient induction of cyclin A in loaded chicken skeletal muscle
J Appl Physiol, October 1, 2003; 95(4): 1664 - 1671.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Kumar, I. Chaudhry, M. B. Reid, and A. M. Boriek
Distinct Signaling Pathways Are Activated in Response to Mechanical Stress Applied Axially and Transversely to Skeletal Muscle Fibers
J. Biol. Chem., November 22, 2002; 277(48): 46493 - 46503.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. D. Boppart, M. F. Hirshman, K. Sakamoto, R. A. Fielding, and L. J. Goodyear
Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle
Am J Physiol Cell Physiol, February 1, 2001; 280(2): C352 - C358.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M Fluck, V Tunc-Civelek, and M Chiquet
Rapid and reciprocal regulation of tenascin-C and tenascin-Y expression by loading of skeletal muscle
J. Cell Sci., January 10, 2000; 113(20): 3583 - 3591.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. P. Quinn, M. Schlueter, S. J. Soifer, and J. A. Gutierrez
Mechanotransduction in the Lung: Cyclic mechanical stretch induces VEGF and FGF-2 expression in pulmonary vascular smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L897 - L903.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online