Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 86: 230-235, 1999;
8750-7587/99 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gross, T. S.
Right arrow Articles by Zernicke, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gross, T. S.
Right arrow Articles by Zernicke, R. F.
Vol. 86, Issue 1, 230-235, January 1999

Bone hyperemia precedes disuse-induced intracortical bone resorption

Ted S. Gross, Ariff A. Damji, Stefan Judex, Robert C. Bray, and Ronald F. Zernicke

McCaig Centre for Joint Injury and Arthritis Research, Department of Surgery, University of Calgary, Calgary, Canada T2N 4N1

An in vivo model was used to determine whether bone hyperemia precedes increased intracortical porosity induced by disuse. Twenty-four adult male roosters (age 1 yr) were randomly assigned to intact-control, 7-days-sham-surgery, 7-days-disuse, and 14-days-disuse groups. Disuse was achieved by isolating the left ulna diaphysis from physical loading via parallel metaphyseal osteotomies. The right ulna served as an intact contralateral control. Colored microspheres were used to assess middiaphyseal bone blood flow. Bone blood flow was symmetric between the left and right ulnae of the intact-control and sham-surgery groups. After 7 days of disuse, median (±95% confidence interval) standardized blood flow was significantly elevated compared with the contralateral bone (6.5 ± 5.2 vs. 1.0 ± 0.8 ml · min-1 · 100 g-1; P = 0.03). After 14 days of disuse, blood flow was also elevated but to a lesser extent. Intracortical porosity in the sham-surgery and 7-days-disuse bones was not elevated compared with intact-control bones. At 14 days of disuse, the area of intracortical porosity was significantly elevated compared with intact control bones (0.015 ± 0.02 vs. 0.002 ± 0.002 mm2; P = 0.03). We conclude that disuse induces bone hyperemia before an increase in intracortical porosity. The potential interaction between bone vasoregulation and bone cell dynamics remains to be studied.

blood flow; bone loss; osteoclast; endothelial cell; vasoregulation


This article has been cited by other articles:


Home page
 RadiologyHome page
L. M. White, T. I. Powell, G. Tomlinson, and E. Boynton
Increased Subcortical Patellar Signal Intensity at T2-weighted MR Imaging: A Subacute Finding after Knee Injury
Radiology, September 1, 2005; 236(3): 952 - 957.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Anetzberger, E. Thein, G. Loffler, and K. Messmer
Fluorescent microsphere method is suitable for chronic bone blood flow measurement: a long-term study after meniscectomy in rabbits
J Appl Physiol, May 1, 2004; 96(5): 1928 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Anetzberger, E. Thein, M. Becker, A. K. Walli, and K. Messmer
Validity of fluorescent microspheres method for bone blood flow measurement during intentional arterial hypotension
J Appl Physiol, September 1, 2003; 95(3): 1153 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. C. Shymkiw, R. C. Bray, S. K. Boyd, A. Kantzas, and R. F. Zernicke
Physiological and mechanical adaptation of periarticular cancellous bone after joint ligament injury
J Appl Physiol, March 1, 2001; 90(3): 1083 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. S. Dodd, J. A. Raleigh, and T. S. Gross
Osteocyte hypoxia: a novel mechanotransduction pathway
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C598 - C602.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online