Journal of Applied Physiology
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J Appl Physiol 86: 222-229, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 1, 222-229, January 1999

Effects of dopamine and domperidone on ventilatory sensitivity to hypoxia after 8 h of isocapnic hypoxia

Michala E. F. Pedersen, Keith L. Dorrington, and Peter A. Robbins

University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom

Acclimatization to altitude involves an increase in the acute hypoxic ventilatory response (AHVR). Because low-dose dopamine decreases AHVR and domperidone increases AHVR, the increase in AHVR at altitude may be generated by a decrease in peripheral dopaminergic activity. The AHVR of nine subjects was determined with and without a prior period of 8 h of isocapnic hypoxia under each of three pharmacological conditions: 1) control, with no drug administered; 2) dopamine (3 µg · min-1 · kg-1); and 3) domperidone (Motilin, 40 mg). AHVR increased after hypoxia (P <=  0.001). Dopamine decreased (P <=  0.01), and domperidone increased (P <=  0.005) AHVR. The effect of both drugs on AHVR appeared larger after hypoxia, an observation supported by a significant interaction between prior hypoxia and drug in the analysis of variance (P <=  0.05). Although the increased effect of domperidone after hypoxia of 0.40 l · min-1 · %saturation-1 [95% confidence interval (CI) -0.11 to 0.92 l · min-1 · %-1] did not reach significance, the lower limit for this confidence interval suggests that little of the increase in AHVR after sustained hypoxia was brought about by a decrease in peripheral dopaminergic inhibition.

acute hypoxic ventilatory response; hypoxic sensitivity; acclimatization


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