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J Appl Physiol 86: 202-210, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 1, 202-210, January 1999

Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice

N. Noviski1,2,6, J. P. Brewer2,5, W. A. Skornik3,6, S. J. Galli4,6, J. M. Drazen2,5,6, and T. R. Martin2,4,5,6

1 Children's Service, Neonatal and Pediatric Intensive Care Units, Massachusetts General Hospital, Boston 02114; 2 Combined Program in Pulmonary and Critical Care Medicine, Beth Israel Hospital and Brigham and Women's Hospital, Boston 02115; 3 Department of Environmental Health, Harvard School of Public Health, Boston 02115; 4 Department of Pathology, Beth Israel-Deaconess Medical Center, Boston 02215; 5 Pulmonary Division, Department of Pediatrics, Children's Hospital, Boston 02115; and 6 Harvard Medical School, Boston, Massachusetts 02115

Exposure to ambient ozone (O3) is associated with increased exacerbations of asthma. We sought to determine whether mast cell degranulation is induced by in vivo exposure to O3 in mice and whether mast cells play an essential role in the development of pulmonary pathophysiological alterations induced by O3. For this we exposed mast cell-deficient WBB6F1-kitW/kitW-v (kitW/kitW-v) mice and the congenic normal WBB6F1 (+/+) mice to air or to 1 or 3 parts/million O3 for 4 h and studied them at different intervals from 4 to 72 h later. We found evidence of O3-induced cutaneous, as well as bronchial, mast cell degranulation. Polymorphonuclear cell influx into the pulmonary parenchyma was observed after exposure to 1 part/milllion O3 only in mice that possessed mast cells. Airway hyperresponsiveness to intravenous methacholine measured in vivo under pentobarbital anesthesia was observed in both kitW/kitW-v and +/+ mice after exposure to O3. Thus, although mast cells are activated in vivo by O3 and participate in O3-induced polymorphonuclear cell infiltration into the pulmonary parenchyma, they do not participate detectably in the development of O3-induced airway hyperresponsiveness in mice.

pulmonary inflammation; asthma

dagger Deceased.




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