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J Appl Physiol 86: 133-138, 1999;
8750-7587/99 $5.00
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Vol. 86, Issue 1, 133-138, January 1999

Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans

Hideo Ikarugi1,2, Tomomi Taka1, Shoko Nakajima1, Takanori Noguchi1, Sadahiro Watanabe3, Yasuto Sasaki1, Shukoh Haga4, Takashi Ueda1, Junji Seki5, and Junichiro Yamamoto1

1 Faculty of Nutrition, Kobe Gakuin University, Kobe 651-2180; 2 Laboratory of Exercise Physiology, Kobe University of Commerce, Kobe 651-2197; 3 Division of Basic Medical Science, Kobe City College of Nursing, Kobe 651-2103; 4 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-0006; and 5 Department of Biomedical Engineering, National Cardiovascular Center Research Institute, Osaka 565-0873, Japan

The effects of exercise and catecholamines on platelet reactivity or coagulation and fibrinolysis appear to be inconsistent. This may be partly due to the methods employed in previous studies. In the present study, we investigated the effects of acute aerobic exercise and catecholamines on the thrombotic status by a novel in vitro method, shear-induced hemostatic plug formation (hemostatometry), using nonanticoagulated (native) blood. Aerobic exercise (60% maximal O2 consumption) was performed by healthy male volunteers for 20 min, and the effect on platelet reactivity and coagulation was assessed by performing hemostatometry before and immediately after exercise. Exercise significantly increased shear-induced platelet reactivity, coagulation, and catecholamine levels. The effect of catecholamines on platelet reactivity and coagulation was assessed in vitro by adding catecholamines to blood collected in the resting state. The main findings of the present study are that elevation of circulating norepinephrine at levels that are attained during exercise causes platelet hyperreactivity and a platelet-mediated enhanced coagulation. This may be a mechanism of an association of aerobic exercise with thrombotic risk.

platelet aggregation; catecholamine; shear stress; hemostatometry


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