Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 2360-2364, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jin, X.
Right arrow Articles by Mason, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jin, X.
Right arrow Articles by Mason, E. J.
Vol. 85, Issue 6, 2360-2364, December 1998

Decreases in organ blood flows associated with increases in sublingual PCO2 during hemorrhagic shock

Xiaohua Jin1, Max Harry Weil1,2, Shijie Sun1,2, Wanchun Tang1,2, Joe Bisera1,2, and Earl J. Mason1

1 Institute of Critical Care Medicine, Palm Springs 92262; and 2 The University of Southern California School of Medicine, Los Angeles, California 90033

Earlier studies demonstrated that not only the stomach but also the esophageal wall served as an appropriate site for estimating the severity of circulatory shock by using tonometric methods. We then conceived of the option of sublingual tonometry. In the present study, we tested the hypothesis that the changes in sublingual PCO2 serve as indicators of decreases in blood flow to sublingual and visceral tissue. In Sprague-Dawley rats, sublingual PCO2 increased from 50 to 127 Torr and arterial blood lactate increased from 0.9 to 11.2 mmol/l during bleeding. Sublingual blood flow simultaneously decreased to ~32% of preshock values. After reinfusion of shed blood, organ blood flows and sublingual PCO2 were promptly restored to near-baseline values. There were corresponding decreases in blood flows in the tongue, stomach, jejunum, colon, and kidneys during hemorrhagic shock. Increases in sublingual PCO2 were highly correlated with decreases in sublingual blood flow (r = 0.80), tongue blood flow (r = 0.81), gastric blood flow (r = 0.74), jejunal blood flow (r = 0.65), colon blood flow (r = 0.80), and renal blood flow (r = 0.75). Unbled control animals demonstrated no significant changes. Therefore, we anticipate that sublingual tonometry will provide a useful, noninvasive alternative for monitoring visceral PCO2.

sublingual carbon dioxide pressure; regional blood flow; rat; tissue hypercarbia


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. A. A. M. Cammarata, M. H. Weil, M. Fries, W. Tang, S. Sun, and C. J. Castillo
Buccal capnometry to guide management of massive blood loss
J Appl Physiol, January 1, 2006; 100(1): 304 - 306.
[Abstract] [Full Text] [PDF]

Home page
 Crit Care NurseHome page
E. J. Bridges and S. Dukes
Cardiovascular Aspects of Septic Shock: Pathophysiology, Monitoring, and Treatment
Crit. Care Nurse, April 1, 2005; 25(2): 14 - 40.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Guzman, M. S. Dikin, and J. A. Kruse
Lingual, splanchnic, and systemic hemodynamic and carbon dioxide tension changes during endotoxic shock and resuscitation
J Appl Physiol, January 1, 2005; 98(1): 108 - 113.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
U. Janssens, H. Groesdonk, J. Graf, P. W. Radke, W. Lepper, and P. Hanrath
Comparison of oesophageal and gastric air tonometry in patients with circulatory failure
Br. J. Anaesth., August 1, 2002; 89(2): 237 - 241.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. C. Rackow, P. O'Neil, M. E. Astiz, and C. M. Carpati
Sublingual Capnometry and Indexes of Tissue Perfusion in Patients With Circulatory Failure
Chest, November 1, 2001; 120(5): 1633 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. KOCH, S. GEIGER, and M. J. R. RAGALLER
Monitoring of Organ Dysfunction in Sepsis/Systemic Inflammatory Response Syndrome: Novel Strategies
J. Am. Soc. Nephrol., February 1, 2001; 12(90001): S53 - S59.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. Yee and I. Susanto
Sublingual Capnometry : In Search of Its Holy Grail
Chest, October 1, 2000; 118(4): 894 - 896.
[Full Text] [PDF]

Home page
 ChestHome page
H. P. Povoas, M. H. Weil, W. Tang, B. Moran, T. Kamohara, and J. Bisera
Comparisons Between Sublingual and Gastric Tonometry During Hemorrhagic Shock
Chest, October 1, 2000; 118(4): 1127 - 1132.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online