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1-Adrenergic-receptor
responsiveness in skeletal muscle during dynamic exercise
Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295
Attenuation of sympathetic vasoconstriction
(sympatholysis) in working muscles during dynamic exercise is
controversial. One potential mechanism is a reduction in
1-adrenergic-receptor
responsiveness. The purpose of this study was to examine
1-adrenergic-receptor-mediated vasoconstriction in resting and working skeletal muscles by using intra-arterial infusions of a selective agonist. Seven mongrel dogs
were instrumented chronically with flow probes on the external iliac
arteries of both hindlimbs and a catheter in one femoral artery. A
selective 1-adrenergic-receptor
agonist (phenylephrine) was infused as a bolus into the femoral artery
catheter at rest and during exercise. All dogs ran on a
motorized treadmill at two exercise intensities (3 and 6 miles/h).
Intra-arterial infusions of the same effective concentration of
phenylephrine elicited reductions in vascular conductance of 76 ± 4, 76 ± 6, and 67 ± 5% (P > 0.05) at rest, 3 miles/h, and 6 miles/h, respectively. Systemic blood
pressure and blood flow in the contralateral iliac artery were
unaffected by phenylephrine. These results do not demonstrate an
attenuation of vasoconstriction to a selective 1-agonist during exercise and
do not support the concept of sympatholysis.
blood flow; sympatholysis; autonomic nervous system; phenylephrine; dogs
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