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J Appl Physiol 85: 2140-2145, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 6, 2140-2145, December 1998

Recovery of free ADP, Pi, and free energy of ATP hydrolysis in human skeletal muscle

Henning Wackerhage1, Uwe Hoffmann1, Dieter Essfeld1, Dieter Leyk1, Klaus Mueller2, and Jochen Zange2

1 Department of Physiology, German Sports University, D-50933 Cologne; and 2 Institute of Aerospace Medicine, Deutsches Zentrum fuer Luft und Raumfahrt, D-51170 Cologne, Germany

We measured significant undershoots of the concentrations of free ADP ([ADP]) and Pi ([Pi]) and the free energy of ATP hydrolysis (Delta GATP) below initial resting levels during recovery from severe ischemic exercise with 31P-nuclear magnetic resonance spectroscopy in 11 healthy sports students. Undershoots of the rate of oxidative phosphorylation would be predicted if the rate of oxidative phosphorylation would depend solely on free [ADP], [Pi], or Delta GATP. However, undershoots of the rate of oxidative phosphorylation have not been reported in the literature. Furthermore, undershoots of the rate of oxidative phosphorylation are unlikely because there is evidence that a balance between ATP production and consumption cannot be achieved if an undershoot of the rate of oxidative phosphorylation actually occurs. Therefore, oxidative phosphorylation seems to depend not only on free [ADP], [Pi], or Delta GATP. An explanation is that acidosis-related or other factors control oxidative phosphorylation additionally, at least under some conditions.

phosphorus nuclear magnetic resonance spectroscopy; exercise; recovery; free energy


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