Journal of Applied Physiology
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J Appl Physiol 85: 2112-2117, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 6, 2112-2117, December 1998

Effect of ventilation distribution on aerosol bolus dispersion and recovery

James S. Brown1, Timothy R. Gerrity2, and William D. Bennett1

1 Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, and 2 Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina 27599

It has been speculated that convective ventilatory inhomogeneities are an important factor influencing aerosol bolus behavior in the compromised lung. Multiple-breath 133Xe washout (MBWXe) is a commonly accepted test of ventilation distribution. By comparing aerosol bolus parameters to MBWXe in 9 healthy subjects and 14 cystic fibrosis patients with mild-to-moderate airway obstruction, we have attempted to discern the effect of altered ventilation distribution on aerosol bolus dispersion and recovery. Aerosol boluses (150-ml width) were delivered to the volumetric penetrations of 250 and 500 ml. Similar tidal volumes (~1.25 liters) and flow rates (0.4 l/s) were used for aerosol bolus and MBWXe maneuvers. Associations between bolus parameters and ventilation distribution were only observed in the cystic fibrosis patients. We conclude that aerosol bolus dispersion and recovery are both influenced by convective ventilatory inhomogeneities induced by airway obstruction in these patients.

aerosol deposition; lung mechanics; obstructive lung disease


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