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1 US Army Institute of Surgical Research, and 2 Brooke Army Medical Center, Fort Sam Houston, Texas 78234; 3 Department of Surgery, University of Florida, Gainesville, Florida 32610; and 4 Department of Surgery, Rhode Island Hospital, Providence, Rhode Island 02903
We evaluated the
effect of long-term inhalation of nitric oxide (NO) on cardiac
contractility after endotoxemia by using the end-systolic
elastance of the left ventricle (LV) as a load-independent contractility index. Chronic instrumentation in 12 pigs included implantation of two pairs of endocardial dimension transducers to
measure LV volume and a micromanometer to measure LV pressure. One week
later, the animals were divided into a control group (n = 6) or a NO group
(n = 6). All animals received
intravenous Escherichia coli
endotoxin (10 µg · kg
1 · h1)
and equivalent lactated Ringer solution. NO inhalation (20 parts/million) was begun 30 min after the initiation of endotoxemia and
was continued for 24 h. In both groups, tachycardia, pulmonary
hypertension, and systemic hyperdynamic changes were noted. The
end-systolic elastance in the control group was significantly decreased
beyond 7 h. NO inhalation maintained the end-systolic elastance at
baseline levels and prevented its impairment. These findings indicate
that NO exerts a protective effect on LV contractility in this model of endotoxemia.
left ventricular function; cardiac contractility; nitric oxide inhalation; endotoxin; hemodynamics
This article has been cited by other articles:
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  T. J. McMahon and A. Doctor Extrapulmonary effects of inhaled nitric oxide: role of reversible s-nitrosylation of erythrocytic hemoglobin. Proceedings of the ATS, January 1, 2006; 3(2): 153 - 160. [Abstract] [Full Text] [PDF]
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 M. Y. Kirov, O. V. Evgenov, V. N. Kuklin, L. Virag, P. Pacher, G. J. Southan, A. L. Salzman, C. Szabo, and L. J. Bjertnaes Aerosolized Linear Polyethylenimine-Nitric Oxide/Nucleophile Adduct Attenuates Endotoxin-induced Lung Injury in Sheep Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1436 - 1442. [Abstract] [Full Text] [PDF]
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 E Belcher, J Mitchell, and T Evans Myocardial dysfunction in sepsis: no role for NO? Heart, June 1, 2002; 87(6): 507 - 509. [Full Text] [PDF]
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I. F. AFULUKWE, R. I. COHEN, G. A. ZEBALLOS, M. IQBAL, and S. M. SCHARF Selective NOS Inhibition Restores Myocardial Contractility in Endotoxemic Rats; However, Myocardial NO Content Does Not Correlate with Myocardial Dysfunction Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 21 - 26. [Abstract] [Full Text]
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 S. Ishihara, J. A. Ward, O. Tasaki, B. A. Pruitt Jr., M. A. Javors, R. A. Cassidy, and D. W. Mozingo Biphasic changes in left ventricular function during hyperdynamic endotoxemia Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1516 - R1524. [Abstract] [Full Text] [PDF]
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