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J Appl Physiol 85: 1903-1908, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 5, 1903-1908, November 1998

Expression of acetylcholine receptor mRNAs in atrophying and nonatrophying skeletal muscles of old rats

Ronald R. Gomes Jr. and Frank W. Booth

Department of Integrative Biology, Pharmacology, and Physiology, University of Texas-Houston Medical School, Houston, Texas 77030

We examined the age-related association in skeletal muscle between atrophy and expression of mRNAs encoding both the gamma -subunit of the nicotinic acetylcholine receptor (AChR), and myogenin, a transcription factor that upregulates expression of the gamma -subunit promoter. Gastrocnemius and biceps brachii muscles were collected from young (2-mo-old), adult (18-mo-old), and old (31-mo-old) Fischer 344/Brown Norway F1 generation cross male rats. In the gastrocnemius muscles of old vs. young and adult rats, lower muscle mass was accompanied by significantly elevated AChR gamma -subunit and myogenin mRNA levels. In contrast, the biceps brachii muscle exhibited neither atrophy nor as drastic a change in AChR gamma -subunit and myogenin mRNA levels with age. Expression of the AChR epsilon -subunit mRNA did not change with age in either gastrocnemius or biceps brachii muscles. Thus changes in skeletal muscle AChR gamma -subunit and myogenin mRNA levels may be more related to atrophy than to chronological age in old rats.

aging; denervation; synapse; muscle wasting


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