Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 1884-1897, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brennick, M. J.
Right arrow Articles by Pack, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brennick, M. J.
Right arrow Articles by Pack, A. I.
Vol. 85, Issue 5, 1884-1897, November 1998

MRI study of regional variations of pharyngeal wall compliance in cats

Michael J. Brennick1, Malcolm D. Ogilvie1, Susan S. Margulies2, Luke Hiller2, Warren B. Gefter3
Allan I. Pack1,4
(With the Technical Assistance of Ed Jensen)

1 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical Center, 2 Department of Bioengineering, University of Pennsylvania, 3 Thoracic Imaging, Department of Radiology, Hospital of the University of Pennsylvania, and 4 Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Upper airway compliance indicates the potential of the airway to collapse and is relevant to the pathogenesis of obstructive sleep apnea. We hypothesized that compliance would vary over the rostral-to-caudal extent of the pharyngeal airway. In a paralyzed isolated upper airway preparation in cats, we controlled static upper airway pressure during magnetic resonance imaging (MRI, 0.391-mm resolution). We measured cross-sectional area and anteroposterior and lateral dimensions from three-dimensional reconstructed MRIs in axial slices orthogonal to the airway centerline. High-retropalatal (HRP), midretropalatal (MRP), and hypopharyngeal (HYP) regions were defined. Regional compliance was significantly increased from rostral to caudal regions as follows: HRP < MRP < HYP (P < 0.0001), and compliance differences among regions were directly related to collapsibility. Thus our findings in the isolated upper airway of the cat support the hypothesis that regional differences in pharyngeal compliance exist and suggest that baseline regional variations in compliance and collapsibility may be an important factor in the pathogenesis and treatment of obstructive sleep apnea.

upper airway; obstructive sleep apnea; magnetic resonance imaging; collapsibility


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. F. Fregosi
Influence of tongue muscle contraction and dynamic airway pressure on velopharyngeal volume in the rat
J Appl Physiol, March 1, 2008; 104(3): 682 - 693.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. M. Ryan and T. D. Bradley
Pathogenesis of obstructive sleep apnea
J Appl Physiol, December 1, 2005; 99(6): 2440 - 2450.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. J Brennick, S. Pickup, L. Dougherty, J. R Cater, and S. T Kuna
Pharyngeal airway wall mechanics using tagged magnetic resonance imaging during medial hypoglossal nerve stimulation in rats
J. Physiol., December 1, 2004; 561(2): 597 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. T. Kuna and M. J. Brennick
Effects of Pharyngeal Muscle Activation on Airway Pressure-Area Relationships
Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 972 - 977.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. T. KUNA
Effects of Pharyngeal Muscle Activation on Airway Size and Configuration
Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1236 - 1241.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online