| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Departments of Health and Kinesiology and of Medical Physiology, Texas A&M University, College Station, Texas 77843; 2 National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711; and 3 Department of Surgery, Allegheny University for Health Sciences, Pittsburgh, Pennsylvania 15212
The purpose of this study was to determine the effects of maturation and aging on cardiac output, the distribution of cardiac output, tissue blood flow (determined by using the radioactive-microsphere technique), and body composition in conscious juvenile (2-mo-old), adult (6-mo-old), and aged (24-mo-old) male Fischer-344 rats. Cardiac output was lower in juvenile rats (51 ± 4 ml/min) than in adult (106 ± 5 ml/min) or aged (119 ± 10 ml/min) rats, but cardiac index was not different among groups. The proportion of cardiac output going to most tissues did not change with increasing age. However, the fraction of cardiac output to brain and spinal cord tissue and to skeletal muscle was greater in juvenile rats than that in the two adult groups. In addition, aged rats had a greater percent cardiac output to adipose tissue and a lower percent cardiac output to cutaneous and reproductive tissues than that in juvenile and adult rats. Differences in age also had little effect on mass-specific perfusion rates in most tissues. However, juvenile rats had lower flows to the pancreas, gastrointestinal tract, thyroid and parathyroid glands, and kidneys than did adult rats, and aged rats had lower flows to the white portion of rectus femoris muscle, spleen, thyroid and parathyroid glands, and prostate gland than did adult rats. Body mass of juvenile rats was composed of a lower percent adipose mass and a greater fraction of brain and spinal cord, heart, kidney, liver, and skeletal muscle than that of the adult and aged animals. Relative to the young adult rats, the body mass of aged animals had a greater percent adipose tissue mass and a lower percent skeletal muscle and skin mass. These data demonstrate that maturation and aging have a significant effect on the distribution of cardiac output but relatively little influence on mass-specific tissue perfusion rates in conscious rats. The old-age-related alterations in cardiac output distribution to adipose and cutaneous tissues appear to be associated with the increases in percent body fat and the decreases in the fraction of skin mass, respectively, whereas the decrease in the portion of cardiac output directed to reproductive tissue of aged rats appears to be related to a decrease in mass-specific blood flow to the prostate gland.
maturation; strain differences
This article has been cited by other articles:
|
|
 |
|
  M. W. Ramsey, B. J. Behnke, R. D. Prisby, and M. D. Delp Effects of aging on adipose resistance artery vasoconstriction: possible implications for orthostatic blood pressure regulation J Appl Physiol, November 1, 2007; 103(5): 1636 - 1643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Woodman, D. W. Trott, and M. H. Laughlin Short-term increases in intraluminal pressure reverse age-related decrements in endothelium-dependent dilation in soleus muscle feed arteries J Appl Physiol, October 1, 2007; 103(4): 1172 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Parnell, J. Ramadoss, M. D. Delp, M. W. Ramsey, W.-J. A. Chen, J. R. West, and T. A. Cudd Placental/Perinatal: Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model Exp Physiol, September 1, 2007; 92(5): 933 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Rodriguez, D. A. Mahle, J. M. Gearhart, D. R. Mattie, J. C. Lipscomb, R. S. Cook, and H. A. Barton Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling Toxicol. Sci., July 1, 2007; 98(1): 43 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Potter, M. G. Zager, and H. A. Barton Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E952 - E964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Behnke, R. D. Prisby, L. A. Lesniewski, A. J. Donato, H. M. Olin, and M. D. Delp Influence of ageing and physical activity on vascular morphology in rat skeletal muscle J. Physiol., September 1, 2006; 575(2): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kitagawa, K. Kanda, M. Sugiura, Y. Tsuboi, A. Ogawa, K. Shimizu, N. Koyama, H. Kamo, T. Watanabe, K. Ren, et al. Effect of Chronic Inflammation on Dorsal Horn Nociceptive Neurons in Aged Rats J Neurophysiol, June 1, 2005; 93(6): 3594 - 3604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Shipley and J. M. Muller-Delp Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms Cardiovasc Res, May 1, 2005; 66(2): 374 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Wilkerson, L. A. Lesniewski, E. M. Golding, R. M. Bryan Jr., A. Amin, E. Wilson, and M. D. Delp Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1652 - H1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Woodman, E. M. Price, and M. H. Laughlin Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries J Appl Physiol, March 1, 2005; 98(3): 940 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sheffield-Moore, C. W. Yeckel, E. Volpi, S. E. Wolf, B. Morio, D. L. Chinkes, D. Paddon-Jones, and R. R. Wolfe Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E513 - E522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Spier, M. D. Delp, C. J. Meininger, A. J. Donato, M. W. Ramsey, and J. M. Muller-Delp Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles J. Physiol., May 1, 2004; 556(3): 947 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Kenney and T. I. Musch Senescence alters blood flow responses to acute heat stress Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1480 - H1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. I. Musch, K. E. Eklund, K. S. Hageman, and D. C. Poole Altered regional blood flow responses to submaximal exercise in older rats J Appl Physiol, January 1, 2004; 96(1): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Russell, C. A. Kindig, B. J. Behnke, D. C. Poole, and T. I. Musch Effects of aging on capillary geometry and hemodynamics in rat spinotrapezius muscle Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H251 - H258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McAllister Endothelium-dependent vasodilation in different rat hindlimb skeletal muscles J Appl Physiol, May 1, 2003; 94(5): 1777 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Woodman, E. M. Price, and M. H. Laughlin Aging induces muscle-specific impairment of endothelium-dependent dilation in skeletal muscle feed arteries J Appl Physiol, November 1, 2002; 93(5): 1685 - 1690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Muller-Delp, S. A. Spier, M. W. Ramsey, and M. D. Delp Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1662 - H1672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Simmons, W. K. Boyes, P. J. Bushnell, J. H. Raymer, T. Limsakun, A. McDonald, Y. M. Sey, and M. V. Evans A Physiologically Based Pharmacokinetic Model for Trichloroethylene in the Male Long-Evans Rat Toxicol. Sci., September 1, 2002; 69(1): 3 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tang, J. R. Vasselli, E. X. Wu, C. N. Boozer, and D. Gallagher High-resolution magnetic resonance imaging tracks changes in organ and tissue mass in obese and aging rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R890 - R899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Wilkerson, P. N. Colleran, and M. D. Delp Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H328 - H334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Levy, J. Lesko, R. J. Krieg Jr., R. A. Adler, and W. Stevens Leptin responses to glucose infusions in obesity-prone rats Am J Physiol Endocrinol Metab, November 1, 2000; 279(5): E1088 - E1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Barazzoni, K. R. Short, and K. S. Nair Effects of Aging on Mitochondrial DNA Copy Number and Cytochrome c Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart J. Biol. Chem., February 4, 2000; 275(5): 3343 - 3347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Dinenno, P. P. Jones, D. R. Seals, and H. Tanaka Limb Blood Flow and Vascular Conductance Are Reduced With Age in Healthy Humans : Relation to Elevations in Sympathetic Nerve Activity and Declines in Oxygen Demand Circulation, July 13, 1999; 100(2): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
