Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 1719-1726, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buerk, D. G.
Right arrow Articles by Lahiri, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buerk, D. G.
Right arrow Articles by Lahiri, S.
Vol. 85, Issue 5, 1719-1726, November 1998

Dopamine, sensory discharge, and stimulus interaction with CO2 and O2 in cat carotid body

D. G. Buerk1,2,3, S. Osanai1, A. Mokashi1, and S. Lahiri1

Departments of 1 Physiology and 2 Bioengineering, and 3 Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

It is hypothesized that carotid body chemosensory activity is coupled to neurosecretion. The purpose of this study was to examine whether there was a correspondence between carotid body tissue dopamine (DA) levels and neuronal discharge (ND) measured from the carotid sinus nerve of perfused cat carotid bodies and to characterize interaction between CO2 and O2 in these responses. ND and tissue DA were measured after changing from normoxic, normocapnic control bicarbonate buffer (PO2 >120 Torr, PCO2 25-30 Torr, pH ~ 7.4) to normoxic hypercapnia (PCO2 55-57 Torr, pH 7.1-7.2) or to hypoxic solutions (PO2 30-35 Torr) with normocapnia (PCO2 25-30 Torr, pH ~ 7.4) or hypocapnia (PCO2 10-15 Torr, pH 7.6-7.8). Similar temporal changes for ND and tissue DA were found for all of the stimuli, although there was a much different proportional relationship for normoxic hypercapnia. Both ND and DA increased above baseline values during flow interruption and normocapnic hypoxia, and both decreased below baseline values during hypoxic hypocapnia. In contrast, normoxic hypercapnia caused an initial increase in ND, from a baseline of 175 ± 12 (SE) to a peak of 593 ± 20 impulses/s within 4.6 ± 0.9 s, followed by adaptation, whereas ND declined to 423 ± 20 impulses/s after 1 min. Tissue DA initially increased from a baseline of 17.9 ± 1.2 µM to a peak of 23.2 ± 1.2 µM within 3.0 ± 0.7 s, then declined to 2.6 ± 1.0 µM. The substantial decrease in tissue DA during normoxic hypercapnia was not consistent with the parallel changes in DA with ND that were observed for hypoxic stimuli.

chemosensory discharge; dopamine release; dopamine microsensors; hypocapnia; hypercapnia; hypoxia; neurosecretion


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
M. Zhang and C. A. Nurse
CO2/pH Chemosensory Signaling in Co-Cultures of Rat Carotid Body Receptors and Petrosal Neurons: Role of ATP and ACh
J Neurophysiol, December 1, 2004; 92(6): 3433 - 3445.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. L. Joris, N. J. Poth, A. M. Djamadar, D. I. Sessler, E. E. Hamoir, T. R. Defechereux, M. R. Meurisse, and M. L. Lamy
Supplemental oxygen does not reduce postoperative nausea and vomiting after thyroidectomy{dagger}
Br. J. Anaesth., December 1, 2003; 91(6): 857 - 861.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Hanaoka, Y. Droma, J. Hotta, Y. Matsuzawa, T. Kobayashi, K. Kubo, and M. Ota
Polymorphisms of the Tyrosine Hydroxylase Gene in Subjects Susceptible to High-Altitude Pulmonary Edema
Chest, January 1, 2003; 123(1): 54 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
V. Goll, O. Akca, R. Greif, H. Freitag, C. F. Arkilic, T. Scheck, A. Zoeggeler, A. Kurz, G. Krieger, R. Lenhardt, et al.
Ondansetron is no More Effective than Supplemental Intraoperative Oxygen for Prevention of Postoperative Nausea and Vomiting
Anesth. Analg., January 1, 2001; 92(1): 112 - 117.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online