| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Zoology, Brigham Young University, Provo, Utah 84602
Previous studies have demonstrated that oxygen consumption and fat oxidation remain elevated in the postexercise period. The purpose of this study was to determine whether malonyl-CoA, an inhibitor of fatty acid oxidation, remains depressed in muscle after exercise. Rats were sprinted for 5 min (40 m/min, 5% grade) or run for 30 min (21 m/min, 15% grade). Red quadriceps malonyl-CoA returned to resting values by 90 min postexercise in the sprinting rats and remained significantly lower at least 90 min postexercise in the 30-min exercise group. AMP-activated protein kinase activity remained significantly elevated (P < 0.05) for 10 min after exercise in both groups. The most rapid rate of glycogen repletion was in the first 30 min postexercise. The respiratory exchange ratio decreased from a nonexercise value of 0.87 ± 0.01 to an average 0.82 ± 0.01 during the 90-min period after 30 min of exercise. Thus muscle malonyl-CoA remains depressed and fat oxidation is elevated for relatively prolonged periods after a single bout of exercise. This may allow fat oxidation to contribute more to muscle energy requirements, thus leaving more glucose for replenishment of muscle glycogen.
carnitine palmitoyl transferase-1; postexercise substrate utilization
This article has been cited by other articles:
|
|
 |
|
  C. Frosig, C. Roepstorff, N. Brandt, S. J. Maarbjerg, J. B. Birk, J. F. P. Wojtaszewski, E. A. Richter, and B. Kiens Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E787 - E795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Dreyer, M. J. Drummond, E. L. Glynn, S. Fujita, D. L. Chinkes, E. Volpi, and B. B. Rasmussen Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery J Appl Physiol, December 1, 2008; 105(6): 1967 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lefort, E. St.-Amand, S. Morasse, C. H. Cote, and A. Marette The {alpha}-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1447 - E1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fujii, N. Jessen, and L. J. Goodyear AMP-activated protein kinase and the regulation of glucose transport Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E867 - E877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Dreyer, S. Fujita, J. G. Cadenas, D. L. Chinkes, E. Volpi, and B. B. Rasmussen Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle J. Physiol., October 15, 2006; 576(2): 613 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Hancock, E. Janssen, and R. L. Terjung Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice J Appl Physiol, February 1, 2006; 100(2): 406 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jessen and L. J. Goodyear Contraction signaling to glucose transport in skeletal muscle J Appl Physiol, July 1, 2005; 99(1): 330 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vankoningsloo, M. Piens, C. Lecocq, A. Gilson, A. De Pauw, P. Renard, C. Demazy, A. Houbion, M. Raes, and T. Arnould Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid {beta}-oxidation and glucose J. Lipid Res., June 1, 2005; 46(6): 1133 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Rubink and W. W. Winder Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase J Appl Physiol, April 1, 2005; 98(4): 1221 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kim, R. S. Solis, E. B. Arias, and G. D. Cartee Postcontraction insulin sensitivity: relationship with contraction protocol, glycogen concentration, and 5' AMP-activated protein kinase phosphorylation J Appl Physiol, February 1, 2004; 96(2): 575 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. LEMIEUX, D. KONRAD, A. KLIP, and A. MARETTE The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases {alpha} and {beta} in skeletal muscle FASEB J, September 1, 2003; 17(12): 1658 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tomas, T.-S. Tsao, A. K. Saha, H. E. Murrey, C. c. Zhang, S. I. Itani, H. F. Lodish, and N. B. Ruderman Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation PNAS, December 10, 2002; 99(25): 16309 - 16313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakamoto and L. J. Goodyear Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Intracellular signaling in contracting skeletal muscle J Appl Physiol, July 1, 2002; 93(1): 369 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Musi, M. F. Hirshman, J. Nygren, M. Svanfeldt, P. Bavenholm, O. Rooyackers, G. Zhou, J. M. Williamson, O. Ljunqvist, S. Efendic, et al. Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes Diabetes, July 1, 2002; 51(7): 2074 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Durante, K. J. Mustard, S.-H. Park, W. W. Winder, and D. G. Hardie Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E178 - E186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Park, S. R. Gammon, J. D. Knippers, S. R. Paulsen, D. S. Rubink, and W. W. Winder Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle J Appl Physiol, June 1, 2002; 92(6): 2475 - 2482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Fisher, J. Gao, D.-H. Han, J. O. Holloszy, and L. A. Nolte Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E18 - E23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Winder Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle J Appl Physiol, September 1, 2001; 91(3): 1017 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Decombaz, B. Schmitt, M. Ith, B. Decarli, P. Diem, R. Kreis, H. Hoppeler, and C. Boesch Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R760 - R769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Terada, T. Yokozeki, K. Kawanaka, K. Ogawa, M. Higuchi, O. Ezaki, and I. Tabata Effects of high-intensity swimming training on GLUT-4 and glucose transport activity in rat skeletal muscle J Appl Physiol, June 1, 2001; 90(6): 2019 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Musi, N. Fujii, M. F. Hirshman, I. Ekberg, S. Fröberg, O. Ljungqvist, A. Thorell, and L. J. Goodyear AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise Diabetes, May 1, 2001; 50(5): 921 - 927. [Abstract] [Full Text]
|
|
|
|
|
|
N. Musi, T. Hayashi, N. Fujii, M. F. Hirshman, L. A. Witters, and L. J. Goodyear AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle Am J Physiol Endocrinol Metab, May 1, 2001; 280(5): E677 - E684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F P Wojtaszewski, P. Nielsen, B. F Hansen, E. A Richter, and B. Kiens Isoform-specific and exercise intensity-dependent activation of 5'-AMP-activated protein kinase in human skeletal muscle J. Physiol., October 1, 2000; 528(1): 221 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Winder and D. G. Hardie AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes Am J Physiol Endocrinol Metab, July 1, 1999; 277(1): E1 - E10. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
