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O2 on-kinetics in isolated in
situ canine muscle
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623; Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale delle Ricerche, I-20090 Segrate (MI); Department of Health and Human Performance, Auburn University, Auburn, Alabama 36849-5323; and Dipartimento di Scienze e Tecnologie Biomediche, Università di Milano, I-20090 Segrate (MI), Italy
The mechanism(s)
limiting muscle O2 uptake
(
O2) kinetics was
investigated in isolated canine gastrocnemius muscles
(n = 7) during transitions from rest
to 3 min of electrically stimulated isometric tetanic contractions
(200-ms trains, 50 Hz; 1 contraction/2 s; 60-70% of peak
O2). Two conditions were
mainly compared: 1) spontaneous
adjustment of blood flow (
) [control, spontaneous (C Spont)]; and
2) pump-perfused
, adjusted ~15 s before contractions at a
constant level corresponding to the steady-state value during
contractions in C Spont [faster adjustment of
O2 delivery (Fast
O2 Delivery)]. During Fast
O2 Delivery, 1-2 ml/min of
10
2 M adenosine were
infused intra-arterially to prevent inordinate pressure increases with
the elevated . The purpose of the study was to
determine whether a faster adjustment of
O2 delivery would affect
O2 kinetics.
was measured continuously; arterial
(CaO2) and popliteal venous
(CvO2)
O2 contents were determined at
rest and at 5- to 7-s intervals during contractions;
O2 delivery was calculated as
· CaO2,
and O2 was calculated as
· arteriovenous O2 content difference. Times to
reach 63% of the difference between baseline and steady-state
O2 during contractions were
23.8 ± 2.0 (SE) s in C Spont and 21.8 ± 0.9 s in Fast
O2 Delivery (not significant). In
the present experimental model, elimination of any delay in
O2 delivery during the
rest-to-contraction transition did not affect muscle
O2 kinetics, which suggests
that this kinetics was mainly set by an intrinsic inertia of oxidative
metabolism.
gas exchange kinetics; muscle oxidative metabolism; submaximal exercise
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