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Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina 27858
The purpose of
this study was to determine whether enzymatic and histochemical
characteristics of human skeletal muscle are altered with aging.
Tissues from the vastus lateralis (VL) and gastrocnemius were analyzed
for citrate synthase (CS) activity and fiber type in 55 sedentary men
(age range 18-80 yr). In this population, CS activity in the
gastrocnemius was negatively related to age
(r = 
0.32,
P < 0.05); there was no relationship
in the VL. Treadmill-determined maximal oxygen consumption was
positively related (r = 0.40, P < 0.05) to CS in the gastrocnemius
but not in the VL. CS activity in the gastrocnemius was 24% lower in
the oldest (
60 yr, n = 10) vs. the
youngest (
30 yr; n = 12) men; there
was no change in CS activity in the VL with aging. No changes in fiber
type were evident with age in either muscle. These data suggest a
reduction in oxidative enzyme activity in human skeletal muscle with
the aging process; this relationship may be muscle-group specific.
exercise; body composition; maximal oxygen consumption; respiratory capacity
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