Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 1299-1306, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pan, L. G.
Right arrow Articles by Forster, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pan, L. G.
Right arrow Articles by Forster, A. L.
Vol. 85, Issue 4, 1299-1306, October 1998

Important role of carotid afferents in control of breathing

L. G. Pan1,2, H. V. Forster1,3, P. Martino1, P. J. Strecker1, J. Beales1, A. Serra1, T. F. Lowry1,3, M. M. Forster1, and A. L. Forster1

1 Department of Physiology, Medical College of Wisconsin, Milwaukee 53226; 2 Program in Physical Therapy, Marquette University, Milwaukee 53233; and 3 Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226

The purpose of the present study was to determine the effect on breathing in the awake state of carotid body denervation (CBD) over 1-2 wk after denervation. Studies were completed on adult goats repeatedly before and 1) for 15 days after bilateral CBD (n = 8), 2) for 7 days after unilateral CBD (n = 5), and 3) for 15 days after sham CBD (n = 3). Absence of ventilatory stimulation when NaCN was injected directly into a common carotid artery confirmed CBD. There was a significant (P < 0.01) hypoventilation during the breathing of room air after unilateral and bilateral CBD. The maximum PaCO2 increase (8 Torr for unilateral and 11 Torr for bilateral) occurred ~4 days after CBD. This maximum was transient because by 7 (unilateral) to 15 (bilateral) days after CBD, PaCO2 was only 3-4 Torr above control. CO2 sensitivity was attenuated from control by 60% on day 4 after bilateral CBD and by 35% on day 4 after unilateral CBD. This attenuation was transient, because CO2 sensitivity returned to control temporally similar to the return of PaCO2 during the breathing of room air. During mild and moderate treadmill exercise 1-8 days after bilateral CBD, PaCO2 was unchanged from its elevated level at rest, but, 10-15 days after CBD, PaCO2 decreased slightly from rest during exercise. These data indicate that 1) carotid afferents are an important determinant of rest and exercise breathing and ventilatory CO2 sensitivity, and 2) apparent plasticity within the ventilatory control system eventually provides compensation for chronic loss of these afferents.

carotid body denervation; breathing; ventilatory carbon dioxide sensitivity; exercise hyperpnea


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. M. Blain, C. A. Smith, K. S. Henderson, and J. A. Dempsey
Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog
J Appl Physiol, May 1, 2009; 106(5): 1564 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. N. Ainslie and J. Duffin
Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1473 - R1495.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. A. Day and R. J. A. Wilson
A negative interaction between brainstem and peripheral respiratory chemoreceptors modulates peripheral chemoreflex magnitude
J. Physiol., February 15, 2009; 587(4): 883 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, B. J. Chenuel, K. S. Henderson, and J. A. Dempsey
The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. central chemoreceptors
J Appl Physiol, August 1, 2007; 103(2): 578 - 586.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. J. Cummings, M. Swart, and P. N. Ainslie
Morning attenuation in cerebrovascular CO2 reactivity in healthy humans is associated with a lowered cerebral oxygenation and an augmented ventilatory response to CO2
J Appl Physiol, May 1, 2007; 102(5): 1891 - 1898.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, J. R. Rodman, B. J. A. Chenuel, K. S. Henderson, and J. A. Dempsey
Response time and sensitivity of the ventilatory response to CO2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors
J Appl Physiol, January 1, 2006; 100(1): 13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Hodges, C. Opansky, B. Qian, S. Davis, J. M. Bonis, K. Krause, L. G. Pan, and H. V. Forster
Carotid body denervation alters ventilatory responses to ibotenic acid injections or focal acidosis in the medullary raphe
J Appl Physiol, April 1, 2005; 98(4): 1234 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Izumizaki, M. Pokorski, and I. Homma
Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse
J Appl Physiol, October 1, 2004; 97(4): 1401 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S.-E. Genest, R. Gulemetova, S. Laforest, G. Drolet, and R. Kinkead
Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat
J. Physiol., January 15, 2004; 554(2): 543 - 557.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. J L M Timmers, W. Wieling, J. M Karemaker, and J. W M Lenders
Denervation of carotid baro- and chemoreceptors in humans
J. Physiol., November 15, 2003; 553(1): 3 - 11.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Fatemian, D. J F Nieuwenhuijs, L. J Teppema, S. Meinesz, A. G L van der Mey, A. Dahan, and P. A Robbins
The respiratory response to carbon dioxide in humans with unilateral and bilateral resections of the carotid bodies
J. Physiol., June 15, 2003; 549(3): 965 - 973.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Q. Liu, J. Kim, J. Cinotte, P. Homolka, and M. T. T. Wong-Riley
Carotid body denervation effect on cytochrome oxidase activity in pre-Botzinger complex of developing rats
J Appl Physiol, March 1, 2003; 94(3): 1115 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. V. Forster
Plasticity in Respiratory Motor Control: Invited Review: Plasticity in the control of breathing following sensory denervation
J Appl Physiol, February 1, 2003; 94(2): 784 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. R. Hodges, H. V. Forster, P. E. Papanek, M. R. Dwinell, and G. E. Hogan
Ventilatory phenotypes among four strains of adult rats
J Appl Physiol, September 1, 2002; 93(3): 974 - 983.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Serra, D. Brozoski, M. Hodges, S. Roethle, R. Franciosi, and H. V. Forster
Effects of carotid and aortic chemoreceptor denervation in newborn piglets
J Appl Physiol, March 1, 2002; 92(3): 893 - 900.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. Hildebrandt, S. Alexander, P. Bartsch, and W. Droge
Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity
Blood, March 1, 2002; 99(5): 1552 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Serra, D. Brozoski, N. Hedin, R. Franciosi, and H. V. Forster
Mortality after carotid body denervation in rats
J Appl Physiol, September 1, 2001; 91(3): 1298 - 1306.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J E Butler, A Anand, M R Crawford, A R Glanville, D K McKenzie, A S Paintal, J L Taylor, and S C Gandevia
Changes in respiratory sensations induced by lobeline after human bilateral lung transplantation
J. Physiol., July 15, 2001; 534(2): 583 - 593.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. R. Rodman, A. K. Curran, K. S. Henderson, J. A. Dempsey, and C. A. Smith
Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia
J Appl Physiol, July 1, 2001; 91(1): 328 - 335.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Fatemian and P. A. Robbins
Physiological and Genomic Consequences of Intermittent Hypoxia: Selected Contribution: Chemoreflex responses to CO2 before and after an 8-h exposure to hypoxia in humans
J Appl Physiol, April 1, 2001; 90(4): 1607 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. K. Curran, J. R. Rodman, P. R. Eastwood, K. S. Henderson, J. A. Dempsey, and C. A. Smith
Ventilatory responses to specific CNS hypoxia in sleeping dogs
J Appl Physiol, May 1, 2000; 88(5): 1840 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. F. Lowry, H. V. Forster, L. G. Pan, A. Serra, J. Wenninger, R. Nash, D. Sheridan, and R. A. Franciosi
Effects on breathing of carotid body denervation in neonatal piglets
J Appl Physiol, December 1, 1999; 87(6): 2128 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. F. Lowry, H. V. Forster, L. G. Pan, M. A. Korducki, J. Probst, R. A. Franciosi, and M. Forster
Effect of carotid body denervation on breathing in neonatal goats
J Appl Physiol, September 1, 1999; 87(3): 1026 - 1034.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online