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J Appl Physiol 85: 973-978, 1998;
8750-7587/98 $5.00
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Vol. 85, Issue 3, 973-978, September 1998

Cytochrome c promoter activity in soleus and white vastus lateralis muscles in rats

Zhen Yan and Frank W. Booth

Department of Integrative Biology, Pharmacology, and Physiology, University of Texas Medical School, Houston, Texas, 77030

Cytochrome c protein and mRNA are 300 and 100% higher, respectively, in the soleus muscle (predominantly slow-twitch oxidative) than the white vastus lateralis (predominately fast-twitch glycolytic) muscle (W. W. Winder, K. M. Baldwin, and J. O. Holloszy. Eur. J. Biochem. 47: 461-467, 1974; M. M. Lai and F. W. Booth. J. Appl. Physiol. 69: 843-848, 1990). However, the mechanisms controlling these differences in cytochrome c mRNA are largely unknown. The present study employed direct plasmid injection techniques to determine whether the proximal promoter (-726 to +610) of the rat somatic cytochrome c gene was more active in the soleus than in white vastus lateralis muscles in rats. No difference between the soleus and white vastus lateralis muscles for the activities of the -726, -631, -489, -326, -215, -159 and -149 cytochrome c promoters was noted. The results of this study suggest that additional elements (outside of -726 to +610) in the cytochrome c gene may be required, or posttranscriptional regulation may account, for the higher cytochrome c mRNA in the slow-twitch oxidative muscle.

mitochondria; direct plasmid injections; muscle fiber types; oxidative capacity


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