Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 962-966, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lambert, G. W.
Right arrow Articles by Jonsdottir, I. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lambert, G. W.
Right arrow Articles by Jonsdottir, I. H.
Vol. 85, Issue 3, 962-966, September 1998

Influence of voluntary exercise on hypothalamic norepinephrine

Gavin W. Lambert and Ingibjorg H. Jonsdottir

Institute of Physiology and Pharmacology, Department of Physiology, Göteborg University, 41390 Göteborg, Sweden

We combined hypothalamic tissue and plasma determinations of norepinephrine, dihydroxyphenylalanine, and dihydroxyphenylglycol with measurements of abdominal fat in voluntary running rats to examine the relationship among exercise training, hypothalamic and sympathetic nervous function, and body fat stores. The hypothalamic concentrations of norepinephrine, dihydroxyphenylalanine, and dihydroxyphenylglycol were reduced after exercise training (P < 0.01), with the amount of norepinephrine being strongly associated with the plasma norepinephrine (r = 0.58, P < 0.05) and dihydroxyphenylglycol (r = 0.65, P = 0.01) concentrations. Exercise training resulted in a diminution in abdominal fat mass (P < 0.01). A strong relationship existed between fat mass and hypothalamic norepinephrine content (r = 0.83, P < 0.001). The presence of a positive relationship between the arterial and hypothalamic norepinephrine levels provides presumptive evidence of an association between noradrenergic neuronal activity of the hypothalamus and sympathetic nervous function. The observation that abdominal fat mass is linked with norepinephrine in the hypothalamus raises the possibility that alterations in body fat stores provide an afferent signal linking hypothalamic function and the activity of the sympathetic nervous system.

rat; fat; catechols; sympathetic nervous system


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
L. C. Michelini and J. E. Stern
Exercise-induced neuronal plasticity in central autonomic networks: role in cardiovascular control
Exp Physiol, September 1, 2009; 94(9): 947 - 960.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. L. Burke, R. G. Evans, J.-L. Moretti, and G. A. Head
Levels of Renal and Extrarenal Sympathetic Drive in Angiotensin II-Induced Hypertension
Hypertension, April 1, 2008; 51(4): 878 - 883.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. T. Higa-Taniguchi, F. C. P. Silva, H. M. V. Silva, L. C. Michelini, and J. E. Stern
Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1717 - R1727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Kiriazis, X.-J. Du, X. Feng, E. Hotchkin, T. Marshall, S. Finch, X.-M. Gao, G. Lambert, J. K. Choate, and D. M. Kaye
Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1359 - H1365.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Beatty, J. M. Kramer, E. D. Plowey, and T. G. Waldrop
Physical exercise decreases neuronal activity in the posterior hypothalamic area of spontaneously hypertensive rats
J Appl Physiol, February 1, 2005; 98(2): 572 - 578.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. Loeliger, T. Briscoe, G. Lambert, J. Caddy, A. Rehn, S. Dieni, and S. Rees
Chronic Placental Insufficiency Affects Retinal Development in the Guinea Pig
Invest. Ophthalmol. Vis. Sci., July 1, 2004; 45(7): 2361 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. M.D. Watson, G. W. Lambert, K. J. Smith, and C. N. May
Urotensin II Acts Centrally to Increase Epinephrine and ACTH Release and Cause Potent Inotropic and Chronotropic Actions
Hypertension, September 1, 2003; 42(3): 373 - 379.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. K. Droste, A. Gesing, S. Ulbricht, M. B. Muller, A. C. E. Linthorst, and J. M. H. M. Reul
Effects of Long-Term Voluntary Exercise on the Mouse Hypothalamic-Pituitary-Adrenocortical Axis
Endocrinology, July 1, 2003; 144(7): 3012 - 3023.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. J. Zammit, S. P. Berzins, J. W. Gill, E. S. Randle-Barrett, L. Barnett, F. Koentgen, G. W. Lambert, R. P. Harvey, R. L. Boyd, and B. J. Classon
Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland
Mol. Cell. Biol., February 1, 2002; 22(3): 946 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Kramer, J. A. Beatty, H. R. Little, E. D. Plowey, and T. G. Waldrop
Chronic exercise alters caudal hypothalamic regulation of the cardiovascular system in hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R389 - R397.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online