Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 85: 935-945, 1998;
8750-7587/98 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holtschlag, D. J.
Right arrow Articles by Nuttall, F. Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holtschlag, D. J.
Right arrow Articles by Nuttall, F. Q.
Vol. 85, Issue 3, 935-945, September 1998

State-space models of insulin and glucose responses to diets of varying nutrient content in men and women

David J. Holtschlag1, Mary C. Gannon2,3, and Frank Q. Nuttall3

1 Metabolic Research Laboratory and Section of Endocrinology, Metabolism, and Nutrition, Minneapolis Veterans Affairs Medical Center, and Departments of 2 Food Science and Nutrition and 3 Medicine, University of Minnesota, Minneapolis, Minnesota 55417

Discrete-time state-space models were developed to describe contemporaneous responses of plasma insulin and glucose of normal human subjects. Male and female subjects ingested three consecutive identical meals from isocaloric diets classified as high-carbohydrate, high-fat, high-protein, or standard. Distinctly different glucose and insulin responses were measured in men and women. A seven-state system of linear equations, three in insulin and four in glucose, was identified and estimated to describe responses in men. A six-state system, three in insulin and three in glucose, describes responses in women. Model simulations at 15-min intervals closely match measured concentrations over a 12-h period. Effects of diet content and meal timing on insulin and glucose concentrations were quantified. Dynamic insulin and glucose responses to isocaloric meals of pure carbohydrate, fat, and protein diets were projected on the basis of models developed from mixed diets. The symmetry of the projections indicates that positive excursions in glucose concentrations associated with carbohydrate intake may be matched with negative excursions associated with fat and protein intake to help manage postmeal glucose excursions.

diabetes; glycemic index; meal composition; high-carbohydrate meals; high-protein meals; high-fat meals


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
M. C Gannon, F. Q Nuttall, A. Saeed, K. Jordan, and H. Hoover
An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
Am. J. Clinical Nutrition, October 1, 2003; 78(4): 734 - 741.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. Geleva, W. Thomas, M. C. Gannon, and J. M. Keenan
A Solubilized Cellulose Fiber Decreases Peak Postprandial Cholecystokinin Concentrations after a Liquid Mixed Meal in Hypercholesterolemic Men and Women
J. Nutr., July 1, 2003; 133(7): 2194 - 2203.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online